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Órgano Oficial de la Asociación Mexicana de Hepatología
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2012, Number 2

Ann Hepatol 2012; 11 (2)

Fulminant hepatitis during self-medication with conjugated linoleic acid

Nortadas R, Barata J
Full text How to cite this article

Language: Spanish
References: 8
Page: 265-267
PDF size: 94.96 Kb.


Key words:

Conjugated linoleic acid, Toxic hepatitis, Fulminant hepatitis, Liver transplantation.

ABSTRACT

The present report describes a 63-year-old female who presented with fulminant hepatic failure requiring liver transplantation caused by a weight loss dietary supplement containing conjugated linoleic acid (CLA). Thorough investigation, including liver biopsy, revealed no other cause of hepatotoxicity. In the last few years, a considerable number of reports have been published on toxic hepatitis, associated with non-conventional products, attributed with weight-reducing properties. We emphasize the importance of taking a cautious approach when consuming herbal supplements for the purpose of weight loss, as all that is “natural” may not always be healthy. Only one report of CLA-induced toxic hepatitis is related in the medical literature.


REFERENCES

  1. Shapiro MA, Lewis JH. Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin Liver Dis 2007; 11: 477-505

  2. Ansari JA. Therapeutic approaches in management of drug-induced hepatotoxicity. J Biol Sci 2010; 10: 386-95.

  3. Lee WM. Drug-induced hepatotoxicity. N Engl J Med 2003; 349: 474-85.

  4. Sanchez W, Maple JT, Burgart LJ, Kamath PS. Severe hepatotoxicity associated with use of a dietary supplement containing usnic acid. Mayo Clin Proc 2006; 81: 541-4.

  5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to conjugated linoleic acid (CLA) isomers and contribution to the maintenance or achievement of a normal body weight (ID 686, 726, 1516, 1518, 2892, 3165), increase in lean body mass (ID 498, 731), increase in insulin sensitivity (ID 1517), protection of DNA, proteins and lipids from oxidative damage (ID 564, 1937), and contribution to immune defences by stimulation of production of protective antibodies in response to vaccination (ID 687, 1519) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 2010; 8: 1794.

  6. Riserus U, Basu S, Jovinge S, et al. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid–induced insulin resistance. Circulation 2002; 106: 1925-29.

  7. Ramos R, Mascarenhas J, Duarte P, et al. Conjugated linoleic acid-induced toxic hepatitis: first case report. Dig Dis Sci 2009; 54: 1141-3.

  8. Tajiri K, Shimizu Y. Practical guidelines for diagnosis and early management of drug-induced liver injury. World J Gastroenterol 2008; 14: 6774-85.




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CÓMO CITAR (Vancouver)

Ann Hepatol. 2012;11