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Órgano Oficial de la Asociación Mexicana de Hepatología
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2015, Number 5

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Ann Hepatol 2015; 14 (5)

Hepatology highlights

Gambaro SE, Giraudi PJ, Tiribelli C, Rosso N
Full text How to cite this article

Language: English
References: 4
Page: 616-617
PDF size: 74.06 Kb.


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Sutter, et al. Development of steatohepatitis in Ob/Ob mice is dependent on Toll-like receptor 4
Sutter, et al. Studies in animals models and human subjects have suggested that leptin signaling may play a causal role in the development of steatohepatitis perpetuating the inflammatory state. However, clinical observations have been conflicting, since serum leptin was linked neither to necroinflammatory grade and the fibrosis stage.


REFERENCES

  1. Pierre N, Deldicque L, Barbé C, Naslain D, Cani PD, Francaux M. Toll-like receptor 4 knockout mice are protected against endoplasmic reticulum stress induced by a highfat diet. PloS One 2013; 8, e65061.

  2. Liu J, Zhuang ZJ, Bian DX, Ma XJ, Xun YH, Yang WJ, Luo Y, et al. Toll-like receptor-4 signalling in the progression of nonalcoholic fatty liver disease induced by high-fat and high-fructose diet in mice. Clin Exp Pharmacol Physiol 2014; 41: 482-8.

  3. Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM Jr, et al. Hepatic TLR4 Signaling in Obese NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol. ajpgi.00304.2014 (2015). doi:10.1152/ajpgi.00304. 2014

  4. Chatani N, Kamada Y, Kizu T, Ogura S, Furuta K, Egawa M, Hamano M, et al. Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis. Liver Int Off J Int Assoc Study Liver (2014). doi:10.1111/liv.12757




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C?MO CITAR (Vancouver)

Ann Hepatol. 2015;14