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2015, Number 5

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Ann Hepatol 2015; 14 (5)

Fecal transplant to mitigate hyperammonemia and hepatic encephalopathy in animal models

Joong KD, Hylemon PB, Bajaj JS
Full text How to cite this article

Language: English
References: 9
Page: 762-763
PDF size: 56.86 Kb.


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Comment:
The paper by Shen, et al. reports on efforts to engineer the gut microbiota to treat hyperammonemia by decreasing the levels of urease positive gut bacteria. After treatment of mice with oral antibiotics and PEG to deplete indigenous bacteria, mice were inoculated with a consortium of 8 bacteria with low urease gene content.


REFERENCES

  1. Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, et al. Engineering the gut microbiota to treat hyperammonemia. J Clin Invest 2015; 125: 2841-50.

  2. Surawicz CM. Fecal microbiota transplantation: what we know and what we need to know. Ann Intern Med 2015; 162: 662-3.

  3. Tranah TH, Vijay GK, Ryan JM, Shawcross DL. Systemic inflammation and ammonia in hepatic encephalopathy. Metab Brain Dis 2013; 28: 1-5.

  4. Tandon P, Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26-42.

  5. Bajaj JS, Gillevet PM, Patel NR, Ahluwalia V, Ridlon JM, Kettenmann B, Schubert CM, et al. A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy. Metab Brain Dis 2012; 27: 205-15.

  6. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, Puri P, Sterling RK, Luketic V, et al. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014; 39: 1113-25.

  7. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, Monteith P, Noble NA, et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014; 60: 940-7.

  8. Bajaj JS, Heuman DM, Sanyal AJ, Hylemon PB, Sterling RK, Stravitz RT, Fuchs M, et al. Modulation of the metabiome by ifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 2013; 8: e60042.

  9. Vilstrup H, Amodio P, Bajaj J, Cordoba J, Ferenci P, Mullen KD, Weissenborn K, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology 2014; 60: 715-35.




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Ann Hepatol. 2015;14