medigraphic.com
SPANISH

Revista Cubana de Plantas Medicinales

ISSN 1028-4796 (Print)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2014, Number 4

<< Back Next >>

Rev Cubana Plant Med 2014; 19 (4)

Wild medicinal plants used by Colombian Kofan Indians to treat cutaneous leishmaniasis

Bernal GJM, López OAF, Murillo PE, Méndez JJ
Full text How to cite this article

Language: Spanish
References: 37
Page: 407-420
PDF size: 216.73 Kb.


Key words:

cutaneous leishmaniasis, leishmania, medicinal plants, Glucantime, ethnopharmacology, ethnobotany, indigenous, Kofan.

ABSTRACT

Introduction: cutaneous leishmaniasis is one of the seven most prevalent tropical diseases worldwide and a health problem in endemic regions.
Objectives: identify the plants traditionally used to treat leishmaniasis by indigenous Kofan doctors from the Putumayo Amazonian foothill in Colombia.
Methods: an ethnobotanical and ethnopharmacological study was conducted of the medicinal plants used by Kofan indigenous doctors from the Colombian Amazonian foothill to treat cutaneous leishmaniasis. The data was supplemented by preliminary phytochemical screening and quantification of the minerals contained in plant ashes using atomic absorption spectrometry.
Results: fourteen plant species were found from 10 families, the most representative of which was Rubiaceae. Acalypha diversifolia Jacq, Trema micrantha (L.) Blume, Copaifera officinalis (Jacq.) L. and Psichotria sp. are the plants most commonly used to treat the disease. Stems and leaves are the most widely used plant parts (42.8 %). They are used topically (69.2 %), as decoction (23 %) or ingested (3.84 %).
Conclusions: identification was made of the traditional topical or oral use of various plant species whose activity could stem from their content of minerals or secondary metabolites. Host involvement could be more complex than just the result of the topical application of ashes or the ingestion of plant decoction.


REFERENCES

  1. Rábago AJ, Asz SD, López L, Baguera J, Solloa ME, Roberto A, et al. Leishmaniasis cutánea. Reporte de un caso. Med Int Mex. 2006 [citado 2011 Abril 20];22(4):343-6. Disponible en: http://www.medigraphic.com/pdfs/medintmex/mim-2006/mim064o.pdf

  2. World Health Organization Technical Report Series. Report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. Geneva. 22–26 March 2010. [citado 2011 Abril 23];202 p. Disponible en: http://apps.who.int/iris/bitstream/10665/44412/1/WHO_TRS_949_eng.pdf

  3. Sandoval CM, Gutiérrez R, Cárdenas R, Ferro C. Especies de género Lutzomyia (Psychodidae, Phlebotominae) en áreas de transmisión de leishmaniasis tegumentaria y visceral en el departamento de Santander en la cordillera oriental de los Andes colombianos. Biomédica. 2006;26(1):218-27.

  4. Cochero S, Anaya Y, Díaz Y, Paternina M, Luna A, Paternina L, et al. Infección natural de Lutzomyia cayennensis con parásitos tripanosomatídeos (Kinetoplastida: Trypanosomatidae) en Los Montes de María, Colombia. Rev. cub. Med. trop. [Revista en la Internet]. 2007 [citado 2011 Abril 28];59(1):0-0. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375- 07602007000100007&lng=es

  5. Hernán HH, Osorio Y, Gore SN, Gómez A, Travi B. Eficacia y toxicidad de los antimoniales pentavalentes (Glucantime® y Pentostam®) en un modelo animal de leishmaniasis cutánea americana: aplicación de la luminometría. Biomédica. 2004;26(4):393-402.

  6. Soto J, Soto P. Estado actual y futuro de la terapia anti-leishmaniásica en Colombia. Biomédica. 2006;(1):194-206.

  7. de Carvalho PB, Ferreira EI. Leishmaniasis phytotherapy. Nature's leadership against an ancient disease. Fitoterapia. 2001;72(6):599-618. [citado 2011 Abril 25]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0367326X0100301X

  8. Costa EV, Pinheiro MLB, Silva JR, Sales BH, Teixeira MC, Fernandes AC, et al. Antimicrobial and antileishmanial activity of essential oil from the leaves of Annona foetida (Annonaceae). Química Nova. 2009;32(1):78-81. [citado 2011 Mayo 03]. Disponible en: http://www.scielo.br/scielo.php?pid=S0100- 40422009000100015&script=sci_arttext

  9. Osorio E, Arango GJ, Jiménez N, Alzate F, Ruiz G, Gutiérrez D, et al. Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. Journal of ethnopharmacology. 2007;111(3):630-5.

  10. Ibáñez-Calero SL, Ruiz G, Michel R. Evaluación de la flora en el Valle de Zongo contra leishmania y chagas. Rev Bol Quim. 2008;25(1):43-52. [citado 2011 Abril 30]. Disponible en: http://www.revistasbolivianas.org.bo/scielo.php?script=sci_arttext& pid=S0250- 54602008000100007&lng=es&nrm=iso&tlng=es

  11. Fournet A, Barrios AA, Muñoz V. Leishmanicidal and trypanocidal activities of Bolivian medicinal plants. Journal of ethnopharmacology. 1994;41(1):19-37. [citado 2011 Mayo 07]. Disponible en: http://www.sciencedirect.com/science/article/pii/037887419490054X

  12. Rocha L, Almeida J, Macedo R, Barbosa-Filho J. A review of natural products with antileishmanial activity. Phytomedicine. 2005;12(6):514-35. [citado 2011 Abril 29]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0944711305000358

  13. Odonne G, Bourdy G, Castillo D, Estevez Y, Lancha-Tangoa A, Alban-Castillo J, et al. Perception of leishmaniasis and evaluation of medicinal plants used by the Chayahuita in Peru. Part II. Journal of ethnopharmacology. 2009;126(1):149-58. [citado 2011 Mayo 8]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874109004425

  14. Mejía CK, Rengifo SE. Plantas medicinales de uso popular en la Amazonía peruana. 2ª ed. Lima: Agencia Española de Cooperación Internacional. 1995. 8.11. [citado 2011 Mayo 15]. Disponible en: http://www.iiap.org.pe/Upload/Publicacion/L017.pdf

  15. Corte Constitucional de Colombia CC. Auto Nº 004 de 2009. Bogotá (Colombia). Corte Constitucional de Colombia. 2009. [citado 2011 Mayo 22] Disponible en: http://www.corteconstitucional.gov.co/relatoria/autos/2009/a004-09.htm

  16. Arango OR, Sánchez SG. Los pueblos indígenas de Colombia en el umbral del nuevo milenio: población, cultura y territorio: bases para el fortalecimiento social y económico de los pueblos indígenas. Bogotá: Departamento Nacional de Planeación; 2004. 3-35.

  17. TRAMIL S. Sitio Tramil. Rev Cubana Plant Med. 2003;8(3):3. [citado 2011 Abril 12]. Disponible en: http://www.funredes.org/tramil/espathl

  18. Poonam K, Singh GS. Ethnobotanical study of medicinal plants used by the Taungya community in Terai Arc Landscape, India. Journal of ethnopharmacology. 2009;123(1):167-76. [citado 2011 Mayo 27]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874109001305

  19. Al-Adhroey AH, Nor ZM, Al-Mekhlafi HM, Mahmud R. Ethnobotanical study on some Malaysian anti-malarial plants: A community based survey. Journal of ethnopharmacology. 2010;132(1):362-4. [citado 2011 Mayo 12]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874110005532

  20. Horwitz W, Latimer GW. Official methods of analysis of AOAC International. 18ª ed. Maryland, USA: AOAC international Gaithersburg, MD; 2005. Caps 18-19-20.

  21. Sandoval D, López D, Suarez O. Estudio fitoquímico preliminar de detección de alcaloides y saponinas en plantas que crecen en Cuba. Rev Cubana de Farm. 1990;24(2):288-96.

  22. Payo A, Oquendo M, Oviedo R. Tamizaje fitoquímico preliminar de plantas que crecen en Holguín. Rev Cubana de Farm. 1996;30(2). [citado 2011 Abril 22]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75151996000200006&lng=es

  23. Lock de Ugaz, O. Análisis fitoquímico y metabolitos secundarios. Capítulo IV. Manual de fitoterapia. EsSalud/OPS, 2001.

  24. Gachet MS, Lecaro JS, Kaiser M, Brun R, Navarrete H, Muñoz RA, et al. Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology. 2010;128(1):184-97. [citado 2011 Mayo 25]. Disponible en: http://www.sciencedirect.com/science/article/pii/S037887411000023

  25. Kvist LP, Christensen S, Rasmussen H, Mejia K, Gonzalez A. Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. Journal of ethnopharmacology. 2006;106(3):390-402. [citado 2011 Mayo 01]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874106000559

  26. Valadeau C, Pabon A, Deharo E, Albán-Castillo J, Estevez Y, Lores FA, et al. Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts. Journal of ethnopharmacology. 2009;123(3):413-22.

  27. Camacho M, Phillipson J, Croft S, Solis P, Marshall S, Ghazanfar S. Screening of plant extracts for antiprotozoal and cytotoxic activities. Journal of ethnopharmacology. 2003;89(2):185-91. [citado 2011 Abril 25]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874103002691

  28. Mishra BB, Kale RR, Singh RK, Tiwari VK. Alkaloids: future prospective to combat leishmaniasis. Fitoterapia. 2009;80(2):81-90. [citado 2011 Abril 26]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0367326X08002165

  29. Ruiz PG, Garavito G, Acebey CL, Arteaga L, Pinzon R, Gimenez TA. Actividad Leishmanicida y Tripanocida de algunas plantas reportadas como medicinales en Colombia. Editora Revista BIOFARBO. 2004;12(12):27-30.

  30. The Center for Food Security & Public Health. Institute for International Cooperation in Animal Biologics. Leishmaniasis (cutánea y visceral). 2010:1-13. College of Veterinary Medicine. Iowa State University. [citado 2011 Junio 2]. Disponible en: http://www.cfsph.iastate.edu/Factsheets/es/leishmaniasis.pdf

  31. Santos AO, Ueda-Nakamura T, Dias Filho BP, Veiga Junior VF, Pinto AC, Nakamura CV. Effect of Brazilian copaiba oils on Leishmania amazonensis. Journal of ethnopharmacology. 2008;120(2):204-8. [citado 2011 Mayo 27]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874108004480

  32. Tasdemir D, Kaiser M, Brun R, Yardley V, Schmidt TJ, Tosun F, et al. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrobial agents and chemotherapy. 2006;50(4):1352-64.

  33. Muzitano MF, Tinoco LW, Guette C, Kaiser CR, Rossi-Bergmann B, Costa SS. The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata. Phytochemistry. 2006;67(18):2071-7. [citado 2011 Abril 29]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0031942206003700

  34. Nour AMM, Khalid SA, Kaiser M, Brun R, Abdalla WE, Schmidt TJ. The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of ethnopharmacology. 2010;129(1):127-30. [citado 2011 Mayo 03]. Disponible en: http://www.sciencedirect.com/science/article/pii/S0378874110001303

  35. Napolitano HB, Silva M, Ellena J, Rodriguez BDG, Almeida ALC, Vieira PC, Oliva G. Thiemann OH. Aurapten, a coumarin with growth inhibition against Leishmania major promastigotes. Braz J Med Biol Res. 2004;37(12):1847-52. [citado 2011 Abril 17]. Disponible en: http://www.scielo.br/pdf/bjmbr/v37n12/5544.pdf

  36. Tempone A, Treiger Borborema S, De Andrade H, de Amorim Gualda N, Yogi A, Salerno Carvalho C, et al. Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families. Phytomedicine. 2005;12(5):382-90. [citado 2011 Abril 23]. Disponible: http://www.sciencedirect.com/science/article/pii/S094471130500022X

  37. Eric S, Cunha LC, Gonçalves ALS, Souza AR, Negrón ACV. Importancia de los Compuestos Inorgánicos en el Tratamiento de la Leishmaniasis. Latin American Journal of Pharmacy. 2007;26(3):454-61. [citado 2011 Mayo 04]. Disponible en: http://www.latamjpharm.org/trabajos/26/3/LAJOP_26_3_4_1_02SLC5N5JH.pdf




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Cubana Plant Med. 2014;19