medigraphic.com
ISSN 1561-3194 (Electronic)

2015, Number 4

<< Back Next >>

Rev Ciencias Médicas 2015; 19 (4)

Acid folic effects over morphometric variables in newborn Wistar rats

González AE, Cabezas AHC

Language: Spanish
References: 11
Page: 652-659
PDF size: 169.11 Kb.


ABSTRACT

Introduction: folic acid consumption represents a health problem worldwide, while several congenital defects are considerable as preventable with enough level of folic acid in mothers.
Objective: to show the effects of acid folic over some morphometrical variables in newborn Wistar rats.
Material and method: an experimental analytic study was carried out in 116 newborn Wistar rats. The variables used are: tail length, biparietal diameter, and body mass. Five groups of two rat each were made up: one target group and four groups treated with folic acid, taking into account dosis and gestation time; the measuring were made on the first and third day after the rats’ birth. The variable analysis were carried out by the calculation of the mean and stadard deviations, and for comparisson of the average numbers a level of significance α ≤ 0,05 were used.
Results: the measuring of the tail length showed statistical significance (P ‹ 0.05) when the target group and the treated groups were compared, the variables biparietal diameter and body mass did not present any statistical significance despite the fact that the measures of the variable body mass in the treated groups were higher than in the target group.
Conclusions: the need for acid folic supply before and during gestation in Wistar rats was proved, due to its influence as cofactor during the fetal life, stimulating the secretion of any of the growing factors during the postnatal life.


REFERENCES

  1. Díaz Marín Miguel E. Ácido fólico. La Habana: Universidad virtual de salud Manuel Fajardo; 2012. Disponible en: http://uvsfajardo.sld.cu/acido-folico [citado 2014 Abr 15]

  2. Rodríguez Domínguez PL, Collazo Cantero I. Embarazo y uso del ácido fólico como prevención de los defectos del tubo neural. Rev Méd Electrón [internet]. 2013[citado 2 may 2014]; 35(2): 105-113. Disponible en: http://scielo.sld.cu/pdf/rme/v35n2/tema02.pdf

  3. Correa Manjarrés Luz M, Sosa Parra BE, Cadavidad Díaz A, Mesa Restrepo SL, López Mancilla LP. Ingesta de hierro y folatos durante el embarazo y su relación con indicadores bioquímicos maternos. Iatreia[internet]. 2012[citado 2 may 2014]; 25(3):199-202. Disponible en: http://www.scielo.org.co/pdf/iat/v25n3/v25n3a02

  4. Arenas Condado B. Interrelación entre vitamna B12 y ácido fólico. Revista Avances. 2011; 8(25):10-15.

  5. Bailey SW, Ayling JE. The extremely slow and variable activity of dihydrofolatereductase in human liver and its implications for high folic acid intake. Proceedings of National Academy of Sciense[internet]. 2009[cited may 4, 2014]; 106(36). Available from: http://www.pnas.org/content/106/36/15424.full

  6. Christen G, Glynn RJ, Chew EY, Albert CM, Mason JAE. Folicacid, Pyridorine and Cyanocobalamin combination treatment an age, related Macular Degeneration in woman. JAMA Internal Medicine[internet]. 2009[cited may 4, 2014]; 169(4):335-341. Available from: http://archinte.jamanetwork.com/article.aspx?articleid=414817

  7. Suárez-Obando F, Ordóñez-Vásquez A, Zarante I. Defectos del tubo neural y ácido fólico: patogenia, metabolismo y desarrollo embriológico: Revisión de la literatura. Rev Colomb Obstet Ginecol [serial on the Internet]. 2010 Mar[cited 2015 June 24]; 61(1): 49-60. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74342010000100007&lng=en

  8. Herrera Batista A, Rojas Rodríguez LY, Bacallao Gallestey J, Lebredo Álvarez I. Efectos protectores del ácido fólico sobre los hepatocitos de conejos machos adolescentes alcohólicos. Rev Cubana Invest Bioméd[serie en internet]. 2007[citado 2 may 2014]; 26(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002007000200007&lng=es&nrm=iso

  9. Zumeta-Dubé M, Herrera-Batista A, González-Bravo M. Efectos del ácido fólico sobre el crecimiento de la descendencia de ratas tratadas con alcohol. Medisur[revista en Internet]. 2013[citado 2014 May 2]; 11(3): [aprox. 4 p.]. Disponible en: http://www.medisur.sld.cu/index.php/medisur/article/view/2478

  10. Gámez M. Repercusiones del déficit nutricional sobre el funcionamiento del intestinodelgado en ratas [Tesis doctoral]. La Habana: Instituto de Ciencias Básicas Preclínicas Victoria de Girón; 1985.

  11. Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, etal. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod[internet]. 2009 [cited may 2014]; 24(3): 562-79. Available from: http://humrep.oxfordjournals.org/content/24/3/562.long




2020     |     www.medigraphic.com