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>Journals >Revista Cubana de Plantas Medicinales >Year 2015, Issue 1


Languer VB, Amaro GF, Ozaki YLK, do Amaral SFC, Paiva LAJ
Effect of camu-camu capsules on blood glucose and lipid profile of healthy adults
Rev Cubana Plant Med 2015; 20 (1)

Language: Portugués
References: 35
Page: 48-61
PDF: 193.99 Kb.


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ABSTRACT

Introduction: camu-camu (Myrciaria dubia [Kunth] McVaugh) is a fruit from the Amazon region that has significant levels of antioxidants, especially vitamin C and flavonoids.
Objective: this study aimed to evaluate the effect of capsules of camu-camu in lipid profile and glucose of young adults.
Methods: were evaluated 18 volunteers of both genders, aged between 21 and 35 years. The volunteers were divided into two groups: 1) intervention group, which received capsules of lyophilized camu-camu containing 320 mg of vitamin C; 2) control group, which received capsules containing 320 mg of synthetic vitamin C. The ingestion of capsules was daily for 15 days and blood samples were collected and analyzed before and after the intervention. Statistical differences in the levels of vitamin C in plasma, fasting glucose and lipid profile were verified by means of Student's “t” test.
Results: was recorded significant increase in serum ascorbic acid and a significant decrease in fasting glucose, total cholesterol and HDL-cholesterol levels in group that received capsules of camu-camu. There was also a significant decrease in LDLcholesterol levels in intervention group. In control group decreased significantly only the levels of fasting glucose. In both groups there was a tendency of reductioni n triglyceride levels, although it has not been significant.
Conclusion: it was concluded that the capsules of camu-camu were more efficient, presenting hypolipidemic and hypoglycemic action in volunteers studied. These results demonstrate the potential benefit of vitamin C and camu-camu health, presenting the fruit as an excellent source of this vitamin.


Key words: Myrciaria dubia (Kunth) McVaugh, intervention, vitamin C, fasting glucose, LDL-cholesterol.


REFERENCIAS

  1. World Health Organization [Internet]. Health Topics. Chronic diseases [acesso 2012 jul 14]. Disponível em: http://www.who.int/topics/chronic_diseases/en/

  2. Kim HY, Kim OH, Sung MK. Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers. J. Am. Coll. Nutr. 2003;22(3):217-23.

  3. Sociedade Brasileira De Cardiologia. IV Diretriz Brasileira sobre Dislipidemias e Prevenção da Aterosclerose. Departamento de Aterosclerose da Sociedade Brasileira de Cardiologia. Arq. Bras. Cardiol. 2007;88(Supl. 1):2-19.

  4. World Health Organization; World Heart Federation, World Stroke Organization. Global Atlas on cardiovascular disease prevention and control [Internet]. Geneva: World Health Organization, 2011 [acesso 2012 jan 7]. Disponível em: http://www.who.int/cardiovascular_diseases/publications/atlas_cvd/en/

  5. Duthie S, Jenkinson A, Crozier A, Mullen W, Pirie L, Kyle J, et al. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Nutr. J. 2006;45(2):113-22. doi 10.1007/s00394-005-0572-9.

  6. Carlsen MH, Halvorsen BL, Holte K, Bohn SK, Dragland S, Sampson L, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr. J. [Internet]. 2010 [acesso 2012 jun 12]; 9(3). Disponível em: http://www.nutritionj.com/content/9/1/3

  7. Mcrae MP. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. J. Chiropr. Med. 2008;7(1):48-58. doi:10.1016/j.jcme.2008.01.002.

  8. Adams AK, Wermuth EO, McBride PE. Antioxidant vitamins and the prevention of Coronary Heart Disease. Am. Fam. Physician. 1999;3(1):895-902.

  9. Scalbert A, Williamson G. Dietary Intake and Bioavailability of Polyphenols. J. Nutr. 2000;130(Supl. 8):2073-85.

  10. Cerqueira FM, Medeiros MHG, Augusto O. Antioxidantes dietéticos: controvérsias e perspectivas. Quím. Nova. 2007;30(2):441-9.

  11. Yuyama K, Yuyama LKO, Valente JP, Silva ACD, Aguiar JPL, Flores WBC, et al. Camu-camu. 1ª ed. São Paulo: Funep, 2010.

  12. Ueda H, Kuroiwa E, Tachibana Y, Kawanishi K, Ayala F, Moriyasu M. Aldose reductase inhibitors from the leaves of Myrciaria dubia (H. B. & K.) McVaugh. Phytomedicine. 2004;11(7):652-6. doi:10.1016/j.phymed.2003.12.002.

  13. Reynertson KA, Yang H, Jiang B, Basile MJ, Kennelly EJ. Quantitative analysis of antiradical phenolic constituents from fourteen edible Myrtaceae fruits. Food Chem. 2008;109(4):883-90. doi:10.1016/j.foodchem.2008.01.021.

  14. Rodrigues RB, Menezes HCD, Cabral LMC, Dornier M, Reynes M. An Amazonian fruit with a high potential as a natural source of vitamin C: the camu-camu (Myrciaria dubia). Fruits. 2001;56(5)345-54.

  15. Yuyama K, Aguiar JPL, Yuyama LKO. Camu-camu: um fruto fantástico como fonte de vitamina C. Acta Amaz. 2002;32(1):169-74.

  16. Tabela Brasileira de Composição de Alimentos. 4.ª ed., Campinas: NEPAUNICAMP, 2011.

  17. World Health Organization. Physical Status: the use and interpretation of anthropometry. [Internet] Geneva: World Health Organization, 1995 [acesso 2012 jan 23]. Disponível em: http://apps.who.int/bookorders/anglais/detart1.jsp?sesslan=1&codlan=1&codcol=1 0&codcch=854

  18. Centers for Disease control and prevention, National Center For Health Statistics. [Internet] National Health and Nutrition Examination Survey III (NHANES III), 2000 [acesso 2012 jun 29]. Disponível em: http://www.cdc.gov/nchs/nhanes.htm

  19. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation [Internet]. Geneva: World Health Organization, 2006 [acesso 2012 jan 8]. Disponível em: http://www.who.int/diabetes/publications/diagnosis_diabetes2006/en/index.html

  20. Lowry OH, Lopez JA, Bessey OA. The determination of ascorbic acid in small amounts of blood serum. Journal of Biological Chemistry. 1945;160(1):609-15.

  21. Costa MJC. Statut vitaminique biochimique [pós-doutorado]. Nancy: Université de Nancy, 1992.

  22. Shingal S, Gupta R, Goyle A. Comparison of Antioxidant Efficacy of Vitamin E, Vitamin C, Vitamin A and Fruits in Coronary Heart Disease: A Controlled Trial. J. Assoc. Physicians. 2001;49(3):327-31.

  23. Mcrae MP. The efficacy of vitamin C supplementation on reducing total serum cholesterol in Human subjects: a review and analysis of 51 experimental trials. J. Chiropr. Med. 2008;5(Supl. 1):2-12.

  24. Gokce N, Keaney JF, Frei B, Holbrook M, Olesiak M, Zachariah BJ, et al. Longterm ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1999;99(1):3234-40. doi: 10.1161/01.CIR.99.25.3234.

  25. Vinson JA, Jang J. In vitro and in vivo lipoprotein antioxidant effect of a citrus extract and ascorbic acid on normal and hypercholesterolemic human subjects. J. Med. Food. 2001;4(4):187-92.

  26. Sharrett AR, Ballantyne CM, Coady SA, Heiss G, Sorlie PD, Catellier D, et al. Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 2001;104(10):1108-13. doi: 10.1161/hc3501.095214.

  27. Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J. Hypertens. 2000;18(4):411-5.

  28. Aldámiz-Echevarría L, Dalmau J, Prieto JA, Andrade F, Sanjurjo P, Elorz J, et al. Ensayo aleatorizado ciego-sencillo sobre los efectos de las vitaminas C y E en la hipercolesterolemia familiar. An. Pediatr. (Barc). 2006;65(2):101-7.

  29. Szaleczky E, Prechl J, Ruzicska E, et al., Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients. Med. Sci. Monit. 1998;4(2):241-4.

  30. Czernichow S, Couthouis A, Bertrais S, Vergnaud AC, Dauchet L, Galan P, et al. Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Am. J. Clin. Nutr. 2006;84(2):395-9.

  31. Fadupin GT, Akpoghor AU, Okunade KA. A comparative study of serum ascorbic acid level in people with and without type 2 diabetes in Ibadan, Nigeria. Afr. J. Med. Med. Sci. 2007;36(4):335-9.

  32. Dakhale GN, Chaudhari HV, Shrivastava M. Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 Diabetes Mellitus: a randomized, double-blind study. Adv. Pharmacol. Sci. [Internet]. 2011 [acesso 2012 jun 16] 2011(1):1-5. Disponvel em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254006/pdf/APS2011-195271.pdf doi:10.1155/2011/195271

  33. Inoue T, Komoda H, Uchida T, Node K. Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties. J. Cardiology. 2008;52(2):127-32. doi:10.1016/j.jjcc.2008.06.004.

  34. Schwertz MC, Maia JRP, Sousa RFS, Aguiar JPL, Yuyama LKO, Lima ES. Efeito hipolipidêmico do suco de camu-camu em ratos. Rev. Nutr. 2012;25(1):35-44. doi 10.1590/S1415-52732012000100004.

  35. Li F, Li W, Fu W, Zhang QE, Koike K. Pancreatic lipase-inhibiting triterpenoid saponins from fruits of acanthopanax senticosus. Chem. Pharm. Bull. 2007;55(7):1087-9.






>Journals >Revista Cubana de Plantas Medicinales >Year 2015, Issue 1
 

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