medigraphic.com
ISSN 1029-3043 (Electronic)

2015, Number 4

Next >>

Medicentro 2015; 19 (4)

Relation of the reproductive behaviour in women according to age and cytogenetic prenatal diagnosis in Placetas

Noche GG, Herrera MM, Noa MMD, Casanova NP

Language: Spanish
References: 15
Page: 209-217
PDF size: 244.94 Kb.


ABSTRACT

Introduction: prevalence of Down syndrome can be a result of the reproductive behaviour due to the maternal age at delivery or due to the cytogenetic prenatal diagnosis.
Objective: to characterize the relation of the reproductive behaviour in women according to age and cytogenetic prenatal diagnosis in Placetas municipality.
Methods: a descriptive study of transversal type was carried out in order to evaluate maternal age in 1440 births and the Down syndromes occurred, regardless of the destiny of the product, in Placetas municipality from January, 2011 to June, 2013; there were also evaluated the parameters of effectiveness of actions of the Community Genetics in cytogenetic prenatal diagnosis for maternal age groups (real and global range, proportion of positivity of the study and prevention). At the same time, results of cytogenetic prenatal and postnatal studies were described, and the ageadjusted prevalence of chromosomal abnormalities and Down syndromes was established, as well as, their relationship with maternal age.
Results: natality over 35 years was of 10.8 % in this period in Placetas, and the age- adjusted prevalence of Down syndrome was of 4,17 % for each thousand born alive in all ages. Proportion of positivity of the study was of 5,95 % at advanced ages, and the prevention of the 100 % of women at advanced maternal age was achieved.
Conclusions: there was a satisfactory range with the prenatal cytogenetic diagnosis in women who had an advanced maternal age and the prevention of the 100 % of Down syndrome was also achieved in this group of women.


REFERENCES

  1. Quiñones Maza OL, Quintana Aguilar J, Méndez Rosado LA, Barrios Mesa A, Suárez Mayedo U, García M, et al. Frecuencias de reordenamientos cromosómicos estructurales acorde a las indicaciones para estudios citogenéticos prenatales y postnatales. Rev Cubana Genét Comunit. [internet]. 2010 [citado 20 jul. 2013];4(3):[aprox. 7 p.]. Disponible en: http://bvs.sld.cu/revistas/rcgc/v4n3/rcgc060310.pdf

  2. Méndez Rosado LA, Nodarse Rodríguez A, Morales Rodríguez E, Barrios Martínez A, Soriano Torres M, Castelvi López A. Diagnóstico prenatal citogenético mediante la hibridación in situ con fluorescencia. Rev Cubana Obstet Ginecol [internet]. 2012 [citado 15 jul. 2013]; 38(1):[aprox. 10 p.]. Disponible en: http://scielo.sld.cu/pdf/gin/v38n1/gin01112.pdf

  3. Qi Q, Zhou X, Jiang Y, Hao N, Zhou J, Zhang L. A rare de novo duplication of chromosome 21q22.12→q22.3 with other concomitant deletion and duplication of small fragments in 21q associated with Down syndrome: Prenatal diagnosis, molecular cytogenetic characterization. Mol Cytogenet. [internet]. 2013 Mar. 6 [citado 24 jul. 2013];6:[aprox. 10 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599797/

  4. Betancourt Gamboa K, Ramírez Milán O, Arrieta García R, Guerra Menéndez J, Muñoz Rodríguez M. Aspectos epidemiológicos asociados a alteraciones del desarrollo en embarazadas añosos. Arch Méd Camagüey [internet]. 2010 [citado 15 jul. 2013];14(2):[aprox. 9 p.]. Disponible en: http://scielo.sld.cu/pdf/amc/v14n2/amc150210.pdf

  5. López Rodríguez Y. Embarazo en la adolescencia y su repercusión biopsicosocial sobre el organismo de la madre y de su futuro hijo. Rev Cubana Enferm [internet]. 2011 [citado 15 jul. 2013];27(4):[aprox. 14 p.]. Disponible en: http://scielo.sld.cu/pdf/enf/v27n4/enf11411.pdf

  6. Valls Hernández M, Safora Enríquez O, Rodríguez Izquierdo A, López Rivas J. Comportamiento del embarazo en mujeres mayores de 40 años. Rev Cubana Obstet Ginecol [internet]. 2009 ene.-mar. [citado 15 jul. 2013];35(1):[aprox. 9 p.]. Disponible en: http://scielo.sld.cu/pdf/gin/v35n1/gin02109.pdf

  7. Marcheco Teruel B. La genética en la Salud Pública: el desfío del acceso de todos a los beneficios. Rev Cubana Genét Comunit [internet]. 2007 [citado 27 abr. 2012];1(1):[aprox. 2 p.]. Disponible en: http://bvs.sld.cu/revistas/rcgc/v1n1/gcoed107.pdf

  8. Pérez Martín MM, Falcón Fonte Y, Licourt Otero D, Cabrera Rodríguez N, Cruz Miranda A. Indicadores de efectividad del asesoramiento genético. Rev Cienc Méd Pinar del Río [internet]. 2012 mayo-jun. [citado 22 feb. 2013];16(3): [aprox. 6 p.]. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1561-31942012000300005&script=sci_arttext

  9. Hernández Triguero Y, Suárez Crespo M, Rivera Esquivel MC, Rivera Esquivel VC. La genética comunitaria en los programas de diagnóstico prenatal. Rev Cienc Méd Pinar del Río [internet]. 2013 mayo-jun. [citado 15 jul. 2013];17(3): [aprox. 6 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942013000300009&lng=es

  10. González García R, Maza Blanes MÁ, Oliva López Y, Menéndez García R. Programa de diagnóstico prenatal citogenético mediante la amniocentesis en Minas de Matahambre. Rev Cienc Méd Pinar del Río [internet]. 2013 mayo-jun. [citado 15 jul. 2013];17(3):[aprox. 7 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561- 31942013000300008&lng=es

  11. Herrera Martínez M. Genética y epidemiología del Síndrome de Down en Villa Clara [tesis]. Santa Clara: Universidad de Ciencias Médicas; 2005.

  12. Algora Hernández AE, García Sosa JM, de la Torre Santos ME. Análisis costo-beneficio del programa de diagnóstico prenatal citogenético en Villa Clara (2004-2008). Medicent Electrón [internet]. 2011 [citado 15 jul. 2013];15(4): [aprox. 8 p.]. Disponible en: http://medicentro.sld.cu/index.php/medicentro/article/viewFile/354/437

  13. Papageorgiou EA, Patsalis PC. Non-invasive prenatal diagnosis of aneuploidies: new technologies and clinical applications Genome Med [internet]. 2012 May 28 [citado 24 jul. 2013];4(5):[aprox. 12 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506912/

  14. W. Liao GJ, Allen Chan KC, Jiang P, Sun H, Leung TY, K. Chiu RW, et al. Noninvasive prenatal diagnosis of fetal trisomy 21 by allelic ratio analysis using targeted massively parallel sequencing of maternal plasma DNA. PLoS One [internet]. 2012 May 29 [citado 23 jul. 2013];7(5):[aprox. 10 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362548/

  15. Miranda Rosales F, Mirón Folgoso C, Balaguer Burón A, Iglesias Vidal E, Pérez Gonzáles I, Cento Pernas D. Pesquisaje ultrasonográfico de marcadores genéticos y malformaciones congénitas mayores. Arch Méd Camagüey [internet]. 2012 mayo-jun. [citado 15 jul. 2013];16(3):[aprox. 10 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552012000300007&lng=es




2020     |     www.medigraphic.com