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ISSN 2007-6800 (Print)

2015, Number 2

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Rev Mex Traspl 2015; 4 (2)

Hepatic injure due to ischemia/reperfusion: mechanisms, activation pathways and future prospects

Guraieb-Trueba M, Flores-Villalba E, Rodríguez-Montalvo C, Tijerina-Gómez L, Castilleja F, Bosques F

Language: Spanish
References: 40
Page: 74-79
PDF size: 204.65 Kb.


ABSTRACT

Every 13 minutes a new name is added to the waiting list as a potential organ receptor, and each day 17 people die while waiting for a transplant. Nowadays, the gap between the number of donors and the patients in the waiting list for an organ is still the predominant limitation for hepatic transplantation; this situation has led to expand the criteria for potential donors and take marginal organs and to expand the donor criteria in order to have more organs for transplantation. Liver dysfunction or liver failure remains a significant clinical problem after liver transplantation, liver tissue resections and hemorrhagic shock. Despite the great advances that have been made to try to elucidate the mechanisms of damage by ischemia/reperfusion; the necessity for a better way to understand the pathophysiology of this harmful process to the liver cells, remains a major concern. Ischemia/reperfusion injury is a phenomenom by which the cellular damage in hypoxic organs, whether this is hot or cold, gets worse after the oxygen flow is restored in the tissue of a specific organ. Hepatic preconditioning is a promising technique in preventing the ischemia/reperfusion injury.


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