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2015, Number 1

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Rev Med UV 2015; 15 (1)

Stem Cell from umbilical cord blood: from research to clinical application

Fernández SV, Ibañez CG, Bello LJM

Language: Spanish
References: 51
Page: 45-52
PDF size: 346.88 Kb.


ABSTRACT

In 1986, Broxmeyer showed that umbilical cord blood (UCB) was a rich source of Hematopoietic Stem Cells (HSC) and Hematopoietic Progenitors Cells (CPH), allowing their use in transplantation CTH / CPH. The first successful allogeneic transplant using CTH / CPH SCU was done 25 years ago which has allowed with the establishment of altruistic unrelated banks, increasing the number of patients who benefit from transplantation CTH / CPH. However, its use has been limited, especially in adults due to the low number of CTH / CPH contained in a unit SCU. Several research groups have studied the cell culture conditions appropriate for maintaining and expanding the CTH / CPH without losing their original biological characteristics. The knowledge gained over the years has enhanced the use of CTH / CPH from SCU in different pathologies. New research currently being undertaken, both in vitro and in vivo are needed for clinical application. In this paper, an approach to on advances in knowledge and application of CTH / CPH is done from SCU and the state that keeps this in our country.


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