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>Journals >Revista Latinoamericana de Patología Clínica y Medicina de Laboratorio >Year 2015, Issue 4


Gallardo-Uribe I, González-Villanueva J, Medina-Torres AG, Arato-Hernández N, Anguiano-Sánchez N, Cázares-Tamez R, Díaz-Olachea C
Premedication: analysis of use and cost implications
Rev Latinoamer Patol Clin 2015; 62 (4)

Language: Español
References: 8
Page: 236-239
PDF: 217.29 Kb.

[Full text - PDF]

ABSTRACT

Introduction: In transfusion medicine, premedication y a very common practice among physicians. There are a few studies about the economical impact of this practice, even when it is a very common practice and there is not a solid base to prescribe premedication. Objectives: To examine the frequency of transfusional reactions, using of premedication and the cost implications in a 3rd level hospital. Material and methods: A prospective, transversal and observational study where transfusion medicine data was analized from random patients from 2009 to 2011. Results: 927 transfusions in 631 patients were analized from November 2009 to June 2011, with a ratio blood components/patients of 1.46:1. From of all transfusions, just 7 presented a reaction (only 0.75%). The use of premedication was given 33% of patients. Given the unit cost, total cost of $ 56,860 pesos on 313 for 210 patients was obtained. Calculating the cost of approximately 4,386 patients per year, the amount for the hospital this practice would be $ 1’182,834 pesos only in medicine. Conclusions: It was found that by far the practice of premedication exceeds the frequency of transfusion reactions and premedication is performed on patients without history or risk factors to develop a reaction during transfusion.


Key words: Premedication, costs, transfusion reactions, blood transfusion.


REFERENCIAS

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  2. Patterson BJ, Freedman J, Blanchette V. Effect of premedication guidelines and leukoreduction on the rate of febrile nonhaemolytic platelet transfusion reactions. Transfus Med. 2000; 10: 199-206.

  3. Sanders RP et al. Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol. 2005; 130 (5): 781-787.

  4. Goodell PP, Uhl L, Mohammed M, Powers AA. Risk of hemolytic transfusion reactions following emergency-release rbc transfusion. Am J Clin Pathol. 2010; 134 (2): 202-206.

  5. Kennedy LD, Case LD, Hurd DD, Cruz JM, Pomper GJ. A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. Transfusion. 2008; 48 (11): 2285-2291.

  6. Geiger TL, Howard SC. Acetaminophen and diphenhydramine premedication for allergic and febrile non-hemolytic transfusion reactions: good prophylaxis or bad practice? Transfus Med Rev. 2007; 21 (1): 1-12.

  7. King KE, Ness PM. Prevention of febrile nonhemolytic and allergic transfusion reactions with pretransfusion medication: is this evidence-based medicine? Transfusion. 2008; 48 (11): 2285-2291.

  8. Wang SE, Lara PN Jr, Lee-Ow A, Reed J, Wang LR, Palmer P et al. Acetaminophen and diphenhydramine as premedication for platelet transfusions: a prospective randomized double-blind placebo-controlled trial. Am J Hematol. 2002; 70 (3): 191-194.






>Journals >Revista Latinoamericana de Patología Clínica y Medicina de Laboratorio >Year 2015, Issue 4
 

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