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2002, Number 2

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Rev Inst Nal Enf Resp Mex 2002; 15 (2)

Hemodynamic record of mongrel dogs.

Sotres-Vega A, Olmos-Zúñiga JR, Jasso-Victoria R, Franco-Oropeza A, Loyola-García U, Santillán-Doherty P

Language: Spanish
References: 13
Page: 69-77
PDF size: 280.18 Kb.


ABSTRACT

Introduction: Mongrel dog is an useful animal model used in research protocols of thoraco-abdominal surgery according with important features like genetic variation and anatomic size. Objective: To report the hemodynamic profile obtained from 50 adult mongrel dogs, which were subjected to thoraco-abdominal surgery in the experimental surgery departments of the Instituto Nacional de Enfermedades Respiratorias and the Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”. Material and methods: Animals were intubated with 100% FIO2, tidal volume of 15 ml/kg and respiratory rate of 20 breaths/min and then catheters were inserted to assess heart rate (HR), cardiac output (CO), maximal inspiratory pressure (MIP), systemic arterial pressure [systolic (SAP), dyastolic (DAP) and mean (MAP)], systemic vascular resistance (SVR), central venous pressure (CVP), pulmonary artery pressure [systolic (SPAP),dyastolic (DPAP) and mean (MPAP)], pulmonary vascular resistance (PVR) and pulmonary capillary wedge pressure (PCWP). Anesthesia was supported with 1% halothane. Results: Mean results ± SD were: HR (113.04 ±21.61 beats/min), CO (2.32±0.88 L/min), MIP (13.32±4.04cmH2O/insp), SAP (108.8±33.37 mmHg), DAP (76.94±29.07mmHg), MAP (86.58 ±30.77 mmHg), SVR (3206±1649dyne/s/cme5), CVP (5.19±2.66cmH2O), SPAP (16.06± 5.96 mmHg), DPAP (5.90±3.55mmHg), MPAP (9.84± 4.39mmHg), PVR (249.48±104.03 dyne/s/cme5) and PCWP (4.93±2.96cmH2O). Conclusions: This report is useful for researchers using this experimental approach both in our departments of experimental surgery research and canine surgery.


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