Sotres-Vega A, Jasso-Victoria R, Olmos-Zúñiga JR, Franco-Oropeza JA, Gutiérrez-Marcos LM, Santillán-Doherty P

Language: Spanish
References: 7
Page: 153-161
PDF size: 87.91 Kb.

ABSTRACT

Introduction: Mongrel dog is a good animal model used in experimental thoracic surgery research according to some important features such as genetic variability and the size of its anatomic structures. Objective: To report results of blood gases and acid-base balance obtained from 50 mongrel adults dogs used for thoraco-abdominal surgery research made in both experimental surgery departments from Instituto Nacional de Enfermedades Respiratorias (INER) and Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán” (INCMNSZ). Material and methods: Dogs were assessed immediately after intubation with an FIO₂ of 1, a tidal volume of 15 mL/kg and a respiratory rate of 20 breaths/min; two catheters were inserted into the femoral artery and femoral vein. Anesthesia was supported with 1% halothane. The assessed parameters were: PaO₂, femoral PvO₂, PaCO₂, femoral PvCO₂, pHa, femoral pHv, SaO₂, femoral SvO₂, CaO₂, femoral CvO₂, HCO₃-a, femoral HCO₃-v, CO₂Ta, femoral CO₂Ta and femoral DavPO₂. Results: Mean results ± SD were: PaO₂ (349.6 ±63.12mmHg), femoral PvO₂ (45.7±10.86 mmHg), PaCO₂ (22.2±4.48mmHg), femoral PvCO₂ (28.7±5.52mmHg), pHa (7.5±0.06), femoral pHv (7.4±0.06), SaO₂ (99.9±0.05%), femoral SvO₂ (77±12.52%), CaO₂ (21.8±0.29 Vol%), femoral CvO₂ (16.1±2.63 Vol%), HCO₃-a (15.45±2.31 mmol/L), femoral HCO₃-v (16.85±2.09 mmol/L), CO₂Ta (16.58±5.72 mmol/L), femoral CO₂Ta (17.64±2.14mmol/L) and femoral DavPO₂ (14.60 ±14.88mmHg). Conclusions: These results are useful as a reference for researchers that use this experimental model, for our departments of experimental surgery research and for those researchers involved in dog pulmonary physiology.

REFERENCES

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