Peñaflor-Juárez K, Guillén-Chan SM, Romero-Juárez Y, Luna-Bautista F, Franco-Gutiérrez E, Arellano- Ocampo JS, Ibáñez-Sánchez R, Domínguez-Contreras ML, Guerra-Márquez Á

Language: Spanish
References: 19
Page: 94-99
PDF size: 73.15 Kb.

ABSTRACT

Background: Hematopoietic stem cells have been used for over 50 years in the treatment of diverse diseases. Umbilical cord blood (UCB) has proved to be a viable source of hematopoietic stem cells for transplantation purposes. The aim was to report the contribution of the umbilical cord blood bank over the past 9 years, in the treatment of various diseases.
Methods: Since 2005 the number of units of blood from the umbilical cord and their use for transplantation in diverse disease were analyzed. A selection of volunteer pregnant women in labor was performed. Umbilical cord blood was obtained from them, which underwent processing, cryopreservation and validation, as well as compatibility test before using for transplantation.
Results: Ten thousand and ninety nine candidates to donation were assessed, from whom 2481 unit of UCB were collected. Of these, 893 unit were processed and cryopreserved for transplantation. In 65 % of cases there was histocompatibility between the cord cell and the receptors. Transplantation was done in 87 patients, 67 % had hematologic neoplasias, who have received 140 units of UCB in 102 transplants. This Bank of UCB ranks second in the world in productivity according to the rate of utility of units in transplantation (3.3 %).
Conclusions: Our bank of UCB has been able to develop a cell line (hematopoietic stem cells) with international quality standards and has been benefi cial for patients served by our institution with need of a transplant mainly in hemato-oncologic patients.

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