Alcaraz J, Oliver A, Sánchez JM, Lajara J

Language: Spanish
References: 7
Page: 294-305
PDF size: 824.07 Kb.

ABSTRACT

Background: The use of platelet growth factors for numerous clinical applications is emerging more strongly, even sometimes surpassing the existing scientific evidence. Still, there is under control in the final content of the product. The application of growth factors, or what is commonly called: platelet-rich-plasma (PRP) is a drug recognized by the different state agencies not without side effects; which implies a perfect knowledge of the different techniques of obtaining and the final composition of the product to track or trace in the patient.
Objective: To dissect the content in growth factors of different cell fractions of total blood centrifuged.
Material and method: A descriptive, serial of clinical cases study was done selecting a sample of 75 Caucasian patients, 40 male and 35 female with the rank of age between 15 and 65, haematologically healthy, following the analytical norms of inclusion for autotransfusion of the Spanish Society of Hematology and Hemotherapy about biochemical, haematological and serological previous to obtain samples of total blood.
Results: In the leukocyte-rich PRPs levels of final growth factors between 7-10 times higher than baseline patient was obtained, with a nearly 45% higher concentration factors type VEGF and TGF-β; while platelet rich PRPs predominated almost 45% greater growth factors type PDGF-AB and IGF-1.
Conclusion: There was prevalence of VEGF and TGF-β growth factors in those enriched leukocyte PRPs, while platelet-PRPs, without leucocytes, have higher concentrations of growth factors type PDGF-AB and IGF-1.

REFERENCES

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