medigraphic.com
ISSN 1561-3070 (Electronic)

2015, Number 4

<< Back Next >>

Rev Cub Oftal 2015; 28 (4)

Adverse reactions of ozone therapy in patients with retinitis pigmentosa

Pérez ALJ, Román GC, Herrera MM, Barrientos CA, Leyva CAM

Language: Spanish
References: 14
Page: 360-365
PDF size: 60.84 Kb.


ABSTRACT

Objective: to describe adverse reactions of ozone therapy after the Cuban strategy for patients with retinitis pigmentosa.
Methods: a retrospective, longitudinal and descriptive study was conducted in 6 414 patients with retinitis pigmentosa seen at "Camilo Cienfuegos" International Center of Retinitis Pigmentosa. They had been treated with ozone therapy as part of the Cuban multi-therapy strategy for management of these patients. A group of patients received ten applications of major autohemotherapy whereas another group was administered 10 ozone sessions through rectal insufflation. The Ozomed machine was the choice for ozone therapy. Student’s test was used to analyze and to compare statistical data. Significant statistical index was p ‹ 0,05.
Results: twenty eight patients were found to have adverse reactions, 5 of them under rectal insufflation and 23 in the major autohemotherapy group. There were observed 4 patients with nauseas, 6 with stomach bloating, 5 with euphoria, one with unusual fatigue and one with strange metallic taste. This represented 0,004% in this sample.
Conclusion: the ozone therapy has been found to be an extremely safe medical therapy in patients with retinitis pigmentosa.


REFERENCES

  1. Viebahn-Haensler R. The use of ozone in medicine. Heidelberg: Haug Publishers; 2002. p. 1-164.

  2. Jacobs MT. Zwischenfalle und typische komplikationen in der Ozon-saverstofftherapie. Baden-Baden: Atti Congresso sull'ozono; 1981:20.

  3. Díaz S, González Y, Prieto EA, Azoy A. Genotoxic effect of ozone in human peripheral blood leukocyte. Mutat Res/Gen Toxicol Environm Mutag. 2002;517:13-20.

  4. Bocci V, Valacchi G, Corradeschi F, Aldinucci C, Silvestri S, Paccagnini E, Gerli R. Studies on the biological effects of ozone: Generation of reactive oxygen species after exposure of human blood to ozone. J Biol Regul. Homeost Agents. 1998;12:67-75.

  5. Bocci V. Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today. J Biol Reg Homeos. 1997;10(2-3):31-53.

  6. Madden MC, Friedmen M, Hanley N, Siegler E, Quay J, Becker S, Devlin R. Chemical Nature and immunotoxicological properties of arachidonic and degradation products formed by exposure to ozone, Environ Health Perspect. 1993;101:154-64.

  7. Bocci V. Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today. J Biol Reg Homeos. 1997;10(2-3):31-53.

  8. Bocci V. A reasonable approach for the treatment of HIV infection in the early phase with ozonetherapy (autohemotherapy). How "inflammatory" cytokines may have a therapeutic role. Mediat Inflamm. 1994;3:315-21.

  9. Viebahn R. The biochemical process underlying ozone therapy. OzoNachrichten. 1985;4:18-30.

  10. Bocci V. Ozone. A new medical drug. AA Dordrecht. The Netherlands: Springer Publishers; 2005. p. 1-28.

  11. Bocci V. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Research. 2006;37:425-35.

  12. Marc RE, Jones BW. Retinal remodeling in inherited photoreceptor degenerations. Mol Neurobiol. 2005;28:139-47.

  13. Jones BW, Watt CB, Frederick JM, Baehr W, Chen CK, Levine EM, Milam AH, Lavail MM, Marc RE. Retinal remodelling triggered by photoreceptor degenerations. J Comp Neurol. 2003;464:1-16.

  14. Copello M, Eguía F, Menéndez S, Menéndez N. Ozone therapy in patients with retinitis pigmentosa. Ozone-Sci Eng. 2003;25(3):223-32.




2020     |     www.medigraphic.com