Chaverri JR, Arce JI, Valverde ZA

Language: Spanish
References: 19
Page: 144-151
PDF size: 998.66 Kb.

ABSTRACT

Acetylsalicylic acid (ASA) is the most commonly used analgesic, antipyretic and antiinflammatory drug worldwide. Acute intoxication is therefore frequent, nonetheless, patients are often not properly recognized or managed. This review consist of two parts, the first paper discusses the pharmacology and pathophysiology of acute salicylism and the second article deals with workup and treatment. Knowledge ofASA pharmacokinetics and pharmacodynamics is vital to understand the clinical presentation and variability. Likewise, comprehension of the pathophysiological mechanism of toxicity ensures an integral approach. The objective of this article is to discuss in an exhaustive and concrete manner the fundamentals that facilitate a reasonable patient management.

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