Arce JI, Valverde ZA, Chaverri JR

Language: Spanish
References: 14
Page: 152-158
PDF size: 1306.82 Kb.

ABSTRACT

Acetylsalicylic acid is the most commonly used analgesic, antipyretic and anti-inflammatory drug worldwide. Acute intoxication is therefore frequent, nonetheless, patients are often not properly recognized or managed. This review consist of two parts, the first paper discusses the pharmacology and pathophysiology of acute salicylism, this second part deals with workup and treatment. The objective of this article is to help the physician to establish a management algorithm in acute salicylism and to understand the therapeutic rationale.

REFERENCES

1. Kerr F Krenzelok E. Salicylates. En: Shannon M Borron S Burns M, eds. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Sanders. 4ta edición, 2007:835- 948.

2. Grosser T Smyth E Fitzgerald G. Antiinflammatory, antipyretic, and analgesic agents. En: Bruton L Chabner B Knollmann B, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill Education. 12va edición, 2010:959-1004.

3. Yip L. Aspirin and Salicylates En: Tintinalli J Stapczynski S Cline D Ma J Cydulka R Meckler G, eds. Tintinalli's emergency medicine: a comprehensive study guide. The American College of Emergency Physicians. 7ma edición, 2010:969.

4. O'Malley GF. Emergency department management of the salicylate-poisoned patient. Emerg Med Clin North Am. 2007;25(2):333- 346.

5. Buckler N Whyte I Dawson A Reith D. Preformatted admission charts for poisoning admissions facilitate clinical assessment and research. Ann Emerg Med. 1999;34(4):476-482.

6. Dargan P. An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose. Emerg Med J. 2002;19(3):206- 209.

7. Wood D Dargan P Jones A. Measuring plasma salicylate concentrations in all patients with drug overdose or altered consciousness: is it necessary? Emerg Med J. 2005;22(6):401-403.

8. Minns A Cantrell F Clark R. Death due to acute salicylate intoxication despite dialysis. J Emerg Med. 2011;40(5):515-517.

9. Vale A. Salycilates. Medicine. 2003;31(10):72-73.

10. Krause D Wolf B Shaw L. Acute aspirin overdose: mechanism of toxicity. Ther Drug Monit. 1992;14(6):441-451.

11. Vale A. Salycilates. Medicine. 2012;40(3):156-157.

12. Kim-Katz S. Salicylates. En: Olson K, eds. Poisoning and drug overdose. McGraw-Hill Professional. 6ta edición, 2011:363-365.

13. Prescott L Balali-Mood M Critchley J Johnstone A Proudfoot A. Diuresis or urinary alkalinisation for salicylate poisoning? Bmj. 1982;285(6352):1383-1386.

14. Juurlink D Gosselin S Kielstein J et al. Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. Ann Emerg Med. 2015;66(2):165-181.