Tabibian JH, Khungar V

Language: English
References: 5
Page: 152-153
PDF size: 122.31 Kb.

Text Extraction

El-Guindi MA et al. Hepatic immunohistochemistry of bile transporters in progressive familial intrahepatic cholestasis El-Guindi MA et al. In this issue of Annals of Hepatology, investigators from the National Liver Institute at Menofiya University aimed to evaluate hepatic expression of proteins involved in bile acid export and homeostasis as a potential means to distinguish progressive familial intrahepatic cholestasis (PFIC) from other causes of neonatal cholestasis. The study included 50 pediatric patients (median age 86.5 days), of whom 25 were diagnosed phenotypically as PFIC (2 with PFIC1, 17 with PFIC2 and 6 with PFIC3) and 25 with a variety of non-PFIC cholestatic disorders. Expression of bile salt export pump (BSEP) and multidrug resistance 3 (MDR3) proteins was assayed in these 50 patients by immunohistochemistry on deparaffinized liver tissue sections from Tru-Cut needle biopsy specimens and compared between groups.

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