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2016, Number 1

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Med Crit 2016; 30 (1)

Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in Intensive Care

Carrillo ER, Meza MJM, Nava LJA, Zepeda MAD, Díaz CMA, Pérez CÁA
Full text How to cite this article

Language: Spanish
References: 20
Page: 10-16
PDF size: 226.16 Kb.


Key words:

uNGAL, acute kidney injury, renal biomarker, renal replacement therapy.

ABSTRACT

Objective: Establish categories of risk for development of severe acute kidney injury based on the combination of levels uNGAL with various clinical variables.
Material and methods: A clinical, retrospective, observational, descriptive and analytical study in the ICU of the Medica Sur Clinic Foundation in understood period of January 1, 2013 to December 31, 2014.
Results: Eighty-two patients included in the study, 37 (45.1%) were male and 45 female (54.9%) with a mean age of 57 ± 20 years. The main cause of admission was septic shock in 57.3%. Creatinine levels and time uresis uNGAL significant differences with a probability less than 0.05. The cutoff for the diagnosis of acute kidney injury admission was 166.8 ng/mL, and the outcome of severe acute kidney injury, the income cutoff was 306.35 ng/mL.
Conclusions: There was no statistically significant difference between variables except for the creatinine levels and urinary lipocalin uresis time. Cutting uNGAL admission to the outcome of severe AKI was 306.35 ng/mL.


REFERENCES

  1. Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet. 2012;380:756-766.

  2. Bagshaw SM, George C, Bellomo R. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care. 2008;12:R47.

  3. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, et al. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care. 2006;10:R73.

  4. Srisawat N, Hoste EE, Kellum JA. Modern classification of acute kidney injury. Blood Purif. 2010;29:300-307.

  5. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:R204-212.

  6. Ricci Z, Cruz DN, Ronco C. Classification and staging of acute kidney injury: beyond the RIFLE and AKIN criteria. Nature reviews. Nephrology. 2011;7:201-208.

  7. Cruz DN, Ricci Z, Ronco C. Clinical review: RIFLE and AKIN time for reappraisal. Crit Care. 2009;13:211.

  8. Clerico A, Galli C, Fortunato A, Ronco C. Neutrophil gelatinaseassociated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences. Clinical Chemistry and Laboratory Medicine. 2012;50:1505-1517.

  9. Devarajan P. Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury. Biomark Med. 2010;4:265-280.

  10. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432:917-921.

  11. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;54:1012-1024.

  12. Grenier FC, Ali S, Syed H, Workman R, Martens F, Liao M, et al. Evaluation of the ARCHITECT urine NGAL assay: assay performance, specimen handling requirements and biological variability. Clin Biochem. 2010;43:615-620.

  13. Makris K, Markou N, Evodia E, Dimopoulou E, Drakopoulos I, Ntetsika K, et al. Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients. Clinical Chemistry and Laboratory Medicine. 2009;47:79-82.

  14. Zappitelli M, Washburn KK, Arikan AA, Loftis L, Ma Q, Devarajan P, et al. Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care. 2007;11:R84.

  15. Ronco C. N-GAL: diagnosing AKI as soon as possible. Crit Care. 2007;11:173.

  16. Cruz DN, de Cal M, Garzotto F, Perazella MA, Lentini P, Corradi V, et al. Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Med. 2010;36:444-451.

  17. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294:813-818.

  18. Ronco C, Ricci Z. The concept of risk and the value of novel markers of acute kidney injury. Critical Care. 2013;17:117.

  19. Ronco C, Kellum JA, Haase M. Subclinical AKI is still AKI. Critical Care. 2012;16:313.

  20. Ronco C, McCullough PA, Chawla LS. Kidney attack versus heart attack: evolution of classification and diagnostic criteria. Lancet. 2013;382:939-940.




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