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Every year, an estimated 7.9 million children worldwide are born with severe birth defects that are totally or partially genetically determined. More than 90% of them are born in low- and middle-income countries lacking the infrastructure to provide the health care these infants need. In the most developed countries, about 30% of these children die in early childhood, 30% receive palliative treatment and live with chronic disability, and the remaining 40% receive curative treatment or have the condition's health impact significantly reduced, mainly through surgery.