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ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2016, Number 1

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Acta Med Cent 2016; 10 (1)

Estudio anatomopatológico del hígado en 200 fallecidos con sepsis grave y grave de alto riesgo

Rodríguez RJM, Montero GTJ, Ygualada CIP, Consuegra CAN

Language: Spanish
References: 20
Page: 9-16
PDF size: 146.52 Kb.


ABSTRACT

Introduction: Sepsis is a systemic response of host to infection that can lead to severe sepsis and septic shock. The liver is a target organ damage from sepsis. Objective: To determine the histopathological characteristics of the liver in those who died with severe and severe sepsis at high risk and relate them to the location of the site of infection and the presence of icterus. Methods: A retrospective, observational, descriptive study in 200 deaths from sepsis. Liver histological patterns were determined and related to the location of the site of infection and icterus and Chi square test was applied. Results: Infiltration by mononuclear was observed in 79%, followed by 78.5% isolated necrosis, sinusoidal dilatation in 74% and 72.5% with hyperplasia of Kupffer cells. The icterus was associated with macrovesicular steatosis (p ‹ 0.01) and with migration of neutrophil to sinusoids (p ‹ 0.05) and abdominal sepsis with apoptosis of hepatocyte and with the microvesicular and macrovesicular steatosis. Discussion: sepsis affects directly the structures and functions of the liver. Intra-abdominal sepsis was associated with apoptosis, while the icterus was associated with macrovesicular steatosis and with migration of neutrophil to sinusoids.


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