2005, Number 09
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ABSTRACTSpermatogenesis arrest is a complex process of interruption in the differentiation of germinal cells of specific cellular type, which elicits an altered spermatozoa formation. In contrast, hypospermatogenesis is defined as a decrease in number of germ cells and its proportion. Factors identified intervening upon spermatogenesis arrest are: genetic, hormonal, growth factors, interaction between Sertoli and germ cells and ectoplasmic specialization integrity of spermatozoa. In addition, environmental toxic effects have shown to exert subletal and letal cellular damage with gene disruption. Hence in this work we review sperm physiology along with etiologic elements associated to spermatogenesis arrest delineating the most appropriate conduct for diagnosis and treatment.
Martín-du Pan, RC. Campana A. Physiopathology of spermatogenic arrest. Fertil Steril 1993;60(6):937-45.
Toyama Y, Maekawa M, Yuasa S. Ectoplasmic specializations in the Sertoli cell: new vistas based on genetic defects and testicular toxicology. Anat Sci Int 2003;78(1):1-16.
Takagi S, Itoh N, Kimura M, Sasao T, Tsukamoto T. Spermatogonial proliferation and apoptosis in hypospermatogenesis associated with nonobstructive azoospermia. Fertil Steril 2001;76(5):901-7.
Lin WW, Lamb DJ, Wheeler TM, et al. Apoptotic frequency is increased in spermatogenic maturation arrest and hypospermatogenic states. J Urol 1997;158(5):1791-3.
Csilla Krausz G, Forti Ken McElreavey. The Y chromosome and male fertility and infertility. Int J Androl 2003;26:70-75.
Szczygiet M, Kurpisz M. Chromosomal anomalies in human gametes and pre-implantation embryos, and their potential effect on reproduction. Andrologia 2001;33(5):249-65.
Aizenstein RI, Di Domenico D, Wilbur AC. Testicular microlithiasis: association with male infertility. J Clin Ultrasound 1998;26(4):195-8.
Diemer T, Ludwig M, Huwe P, Hales DB, Weidner W. Influence of urogenital infection on sperm function. Curr Opin Urol 2000; 10(1):39-44.
Jamal AA, Mansoor I. Morphological profile of testicular biopsies associated with infertility. Saudi Med J 2001;22(11): 992-4.
Skakkebaek, Niels E, Giwercman A, De Kretser D. Pathogenesis and management of male infertility. Fertil Steril 1994;343(8911):1473-9.
Schill WB, Kohn FM. Therapy of male subfertility. Wien Med Wochenschr 1997;147(4-5):76-80.
Adamopoulos DA. Present and future therapeutic strategies for idiopathic oligozoospermia. Int J Androl 2000;23(6):320-31.
Zelel Y, Draysen E, Goldschmit R, et al. A prospective pilot study of co-treatment with growth hormone and gonadotropins for improving spermatogenesis in normogonadotropic patients with severe oligoteratoasthenospermia. Gynecol Endocrinol 1996;10(1):23-28.
Fernández Arjona M, Diaz J, Cortés I, et al. Relationship between gonadotrophin secretion, inhibin B and spermatogenesis in oligozoospermic men treated with highly purified urinary follicle –stimulating hormone (FSH-HP): a preliminary report. Eur J Obstet Gynecol Reprod Biol 2003;26;107(1):47-51.
Tesarik J, Nagy P, Abdelmassih R, Greco E, Mendoza C. Pharmacological concentrations of follicle-stimulating hormone and testosterone improve the efficacy of in vitro germ cell differentiation in men with maturation arrest. Fertil Steril 2002;77(2):245-51.
Ter-Avanesov GV, Ovsiannikova TV, Fanchenko ND, Balika ID. The clinical use of andriol in the hormonal therapy of male sterility. Urol Nefrol (Mosk) 1997;4:29-32.
Fujisawa M, et al. Growth hormone releasing hormone test for infertile men with spermatogenetic maturation arrest. J Urol 2002;168(5):2083-5.
Tiitinen A, Valimaki M. Primary infertility in 45-year-old man with untreated 2l-hydroxylase deficiency: successful outcome with glucocorticoid therapy. J Clin Endocrinol Metab 2002;87(6):2442-5.
Cozzolino DJ, Lamb DJ. Germ cell transplantation: a potential treatment of severe testicular failure. Curr Urol Rep 2000;1(4):262-5.
Kliesch S, Beher HM, Jurgens H, Nieschlag E. Cryopreservation of semen from adolescent patients with malignancies. Med Pediatr Oncol 1996;26(1):20-27.
Schoor RA, Elhanbly S, Niederberger CS, Ross LS. The role of testicular biopsy in the modern management of male infertility. J Urol 2002;167(1):197-200.
Gilbaugh JH, Lipshultz IL. Nonsurgical treatment of male infertility. An update. Urol Clin North Am 1994;21(3):531-43.
Su LM, Palermo GD, Goldstein M, et al. Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive azoospermia: testicular histology can predict success of sperm retrieval. J Urol 1999;161(1):112-6.
0kada H, Dobashi M, Yamazaki T, et al. Conventional versus microdissection testicular sperm extraction for nonobstructive azoospermia. J Urol 2002;168(3):1063-7.
Campbell AJ, Stewart ID. Male infertility and intracytoplasmic sperm injection (ICSI). Br Med Bull 2000;56(3):616-9.