medigraphic.com
Órgano Oficial de la Asociación Mexicana de Hepatología

2011, Number 3

Next >>

Ann Hepatol 2011; 10 (3)

Hepatology Highlights

Méndez-Sánchez N

Language: English
References: 8
Page: 247-248
PDF size: 53.40 Kb.


Text Extraction

Is pre-treatment liver biopsy necessary for all hepatitis C genotypes? Peltekian KM, et al. In this study authors retrospectively compared the sustained viral response (SVR) in 985 treatment-naïve patients with hepatitis C who did or did not undergo liver biopsy before starting peginterferon alfa-2a plus ribavirin. The results showed that physicians elected to treat 141/654 (21.6%) genotype-1 patients and 126/331 (38.1%) genotype-2/3 patients without liver biopsy. SVR rate was no different amongst genotype-2/3 patients who had a biopsy before treatment with 66.3% SVR vs. 69.8% of those treated without biopsy (p = 0.546), but significantly higher among genotype-1 patients with pre-treatment liver biopsy at 54.6 vs. 44.0% for those treated without a liver biopsy (p = 0.029).


REFERENCES

  1. Le MD, Henson D, Young H, Albores-Saavedra J. Is gallbladder cancer decreasing in view of increasing laparoscopic cholecystectomy? Ann Hepatol 2011.

  2. Lazcano-Ponce EC, Miquel JF, Muñoz N, et al. Epidemiology and Molecular Pathology of Gallbladder Cancer. CA Cancer J Clin 2001; 51: 349-64.

  3. Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology 1999; 117: 632-9.

  4. Hyvärinen H, Partanen S. Association of cholecystectomy with abdominal cancers. Hepatogastroenterology 1987; 34: 280-4.

  5. Ruhl CE, Everhart JE. Gallstone disease is associated with increased mortality in the United States. Gastroenterology 2011; 140: 508-16.

  6. Méndez-Sánchez N, Bahena-Aponte J, Chavez-Tapia NC, et al. Strong association between gallstones and cardiovascular disease. Am J Gastroenterol 2005; 100: 827-30.

  7. Bortnichak EA, Freeman DH Jr, Ostfeld AM, et al. The association between cholesterol cholelithiasis and coronary heart disease in Framingham, Massachusetts. Am J Epidemiol 1985; 121: 19-30.

  8. Wysowski DK, Goldberg EL, Comstock GW, et al. A study of a possible association between breast cancer and gallbladder disease. Am J Epidemiol 1986; 123: 532–43.




2020     |     www.medigraphic.com