Figueroa-Sánchez GE, Arreola-Guerra JM, Morales-Buenrostro LE

Language: English
References: 22
Page: 20-26
PDF size: 263.40 Kb.

ABSTRACT

Background: Urinary tract infection (UTI) is a leading cause of morbidity post-kidney transplantation (post-KT). The objective of this study was to describe the microbiological and antimicrobial susceptibility pattern of early UTIs in kidney transplant recipients (KTRs) in our hospital. Methods: This was a retrospective cohort study of patients undergoing a KT from Jan/2008 to Dec/2010. Results: Of the 143 KTRs, 52 developed at least one episode of UTI, representing an incidence of 36.36% in six months. The first episode of UTI occurred within 10 days post-KT in 34 patients (65.38%). E. coli was the most commonly isolated bacteria, representing 67.85% of all cases. The rates of antimicrobial resistance were as follows: trimethoprim-sulfamethoxazole, 85.18%; ampicillin, 91%; ampicillin-sulbactam, 62.5%; ciprofloxacin, 43%; ceftriaxone, 35%; and ceftazidime, 36%. Conversely, meropenem, imipenem, ertapenem and amikacin were highly effective (100%), while 76 and 94% of the isolates were sensitive to piperacillin-tazobactam and fosfomycin, respectively. Conclusions: The incidence of early UTIs post-KT was 36.36%. Most UTIs occurred during the first 10 days post-KT. We found high rates of antimicrobial resistance to TMP-SMZ and other oral antimicrobials. These findings indicate that a critical analysis of modifiable risk factors and the current prophylaxis strategy in our center is required.

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