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Academia Mexicana de Neurología, A.C.

2015, Number 2

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Rev Mex Neuroci 2015; 16 (2)

Case reports on two sisters with pituitary adenoma in the Toluca Medical Center, Metepec, Estado de México

Dhaity-Dhaity G, Urbina-Martínez E, Rodríguez-Vallejo F, Lara-Torres CO, Nuñez-Zárate P

Language: Spanish
References: 11
Page: 55-61
PDF size: 116.15 Kb.


ABSTRACT

Introduction: Pituitary adenoma is considered the third brain tumor in order of frecuency after gliomas and mengiomas and constitute 10% of primary brain tumors. To our knowledge, no case report exist on non twin sisters without multiple endocrine neoplasia (MEN)-1.
Cases report: We report two not twin sisters that consulted for the first time with acromgealy and whose eellar magnetic resonance imagin informed on pituitary adenoma and who undergone neuroendoscopical transfenoidal intervention. Hystopatological examination confirmed the existence of pituitary macroadenoma.
Conclusion: The presentation of pituitary adenoma without MEN-I is more frecuent in men than in women with a 2:1 ratio, more common in the first two decades of life. This report describes two sister simultaneousely affected pituitary adenoma, which suggests that other genetic or environmental factors than the gene for arylhidrocarbon receptor may contribute to the origin of this abnormal tissue proliferation.


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