Bravo-Soto JCG, Pomposo-Espíndola MA, Badillo-Martínez F

Language: Spanish
References: 13
Page: 10-14
PDF size: 445.29 Kb.

ABSTRACT

Background: Postoperative nausea and vomiting (PONV) are a frequent complication of surgery, anesthesia and analgesia with opioids. The frequency of PONV in patients reaches as high as 20 and 50% values, which is the final challenge of the anesthetic therapy and a big problem for outpatient surgery.
Objective: To evaluate the efficacy of granisetron in preventing postoperative nausea and vomiting in ambulatory laparoscopic cholecystectomy.
Method: A group of 40 female patients undergoing ambulatory laparoscopic cholecystectomy, at the Outpatient Surgery Specialist Hospital Dr. Alberto Pisanty Ovadia, ISSSTE, was studied. The average age was 29.6 years, ASA I and II classification. The group I (n=20) was administered 1 mg of granisetron in pre-anesthetic induction and group II (n=20) placebo single dose: two randomized groups were formed. Both groups received balanced general anesthesia. Once you finished the surgical procedure, the presence of nausea and vomiting postanesthesia evaluated at 0, 60, 120 and 180 minutes using the visual analogue scale (VAS).
Results: No patient in group I (granisetron 1 mg) reported nausea and vomiting at all times evaluated, on the other 5% of patients (n=1) in group II referred enter the recovery room with mild nausea, whereas at 60 minutes 65% (n=13) had mild nausea and 5% (n=1 patient) referred moderate nausea. In its evaluation of 120 minutes; 30% of patients (n=6) reported mild nausea, but in its evaluation of 180 minutes, only 10% (n=2) had mild nausea.
Conclusions: Granisetron is effective as a prophylactic treatment of postoperative emesis in patients undergoing outpatient laparoscopic cholecystectomy.

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