Morales-García VD, Garza-Mercado R, Tamez-Montes D, Martínez-Ponce LA

Language: Spanish
References: 7
Page: 128-132
PDF size: 175.20 Kb.

ABSTRACT

To determine the efficacy of administration prophylactic Intraventricular vancomycin in patients with ventriculostomy. Material and method: from December 2003 to November 2004. The study was performed randomized, blind and prospective with case control. Patients with sterile hydrocephaly were administered 10 mg of vancomicyn per application into ventriculstomy for no more than 10 days. Prophylactic efficacy and security were evaluated. Results: 10 patients in case group and 17 in control group were included. Intraventricular hemorrhage was the most common cause of hydrocephalus. No infection was reported in the group case but 47% were infected in the control group. Staphylococcus was the most common cause of infection. No secondary effect was documented for application of intraventricular vancomycin. Conclusion: the prophylactic treatment of intraventricular van-comycin on patients with ventriculostomy was effective and secure.

REFERENCES

1. Lozier AP, Sciacca R, Romagnoli M, Connolly E. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery 2002; 51:170-82.

2. Zingale A, Ippolito S, Pappalardo P, Chibbaro S, Amoroso R. Infections and re-infections in long-term external ventricular drainage. J Neurosurg Sci 1999; 43:125-33.

3. Zabramski J, Whiting D, Daroiche R, Horner T, Olson J. Efficacy of antimicrobial-impregnated external ventricular drain catheters: a prospective, randomized, controlled trial. J Neurosurg 2003; 98:725-30.

4. Pfausler B, Spiss H, Beer R, Kampfl A, Engelhardt K. Treatment of staphylococcal ventriculitis associated with external cerebrospinal fluid drains: a prospective randomized trial of intravenous compared with intraventricular vancomycin therapy. J Neurosurg 2003; 98:1040-4.

5. Brown FM. The management of neurosurgical patients with postoperative bacterial or aseptic meningitis or external ventricular drain-associated ventriculitis. Br J Neurosurg 2000; 14:7-12.

6. Myhall C, Aecher N, Lamb A, Spadora A, Baggett J. Ventri-culostomy-related infections. N Engl J Med 1984; 310:553-9.

7. Alemán-Guzmán J, Herrera-Guerrero M, Revuelta-Gutiérrez R. Utilidad de la ventriculostomía de trayecto subcutáneo largo para dismnuir la incidencia de ventriculitis nosocomial. Arch Neurocien (Mex)1999; 4:117-22.