medigraphic.com
ISSN 1729-519X (Print)

2016, Number 3

<< Back

Revista Habanera de Ciencias Médicas 2016; 15 (3)

Tubular glomerulus unbalance in children and adolescents with a history of low birth weight

Espinosa SI, Borges ML, Pérez RA, Barber FMO, Pérez MA

Language: Spanish
References: 20
Page: 484-493
PDF size: 120.39 Kb.


ABSTRACT

Introduction: The tubular glomerulus unbalance with tubular preponderance may contribute to the hypertension onset. This hypertensor mechanism is proposed starting from obtaining a hypertension experimental model, achieves with the administration of inhibitors of the renin-angiotensin system. It has not been studied if this same mechanism contributes to the development of hypertension that appears in individual’s adulthood with anamnesis of low birth weight due to an intrauterine growth retardation.
Objective: To evaluate the existence of tubular glomerulus unbalance with tubular preponderance in normotensive individuals with a medical record of low birth weight due to an intrauterine growth retardation.
Material and Methods: 78 normotensive children and teenagers were studied. Of these, 19 were between 4 and 5 years (N-IUGR) and 20 from 14 to 15 years (AIUGR) with a medical history of intrauterine growth retardation, the rest constituted the respective control groups. Mean arterial tension, glomerular filtration intensity and sodium proximal tubular reabsorption was determined.
Results: Increase of mean arterial tension values in teenagers with medical records of Retarded Intrauterine Growth (A-CIUR x = 86.3 ± 8.6 vs. A-Control x = 80.9 ± 4.7) were found. Glomerular Filtration Intensity and endogenous lithium clearance showed no differences. Na/Li countertransporter activity of erythrocyte decreased in both groups (N-CIUR x = 4.8 * ± 2.4 vs N-Control x = 7.9 ± 4.0) and (A-CIUR x = 1.9 * * ± 0.7 vs A-Control x = 9.6 ± 1.1).
Conclusions: There is insufficient evidence to deny or confirm the existence of tubular glomerulus unbalance with a tubular glomerulus predominance in the studied individuals.


REFERENCES

  1. 1 . Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL,Jr, Jones DW, Materson BJ, Oparil S, Wright JT,Jr, Roccella EJ. The National High Blood Pressure Education Program Coordinating Committee. The eight report of the Joint National Committee on Detection Evaluation and Treatment of High Blood Pressure. JAMA. 2014; 311:5

  2. World Health Report. Reducing risks, promoting healthy life. Geneva, Switzerland: World Health Organization. 2002. [Consulta 6 agosto 2014]. Disponible en: URL: http://www.who.int/whr/2002/

  3. Prevalencia en Pacientes Dispensarizados por algunas Enfermedades según grupos de Edad y Sexo. Anuario Estadístico de Salud en Cuba. 2000, 2001, 2003, 2004, 2005,2006.

  4. Guyton AC, Hall JE. Texbook of medical physiology, 11th Ed. Philadelphia: Elsevier Publisher; 2012, p. 236-248.

  5. Barker DJP, Winter PD, Osmond C y cols. Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 2: 577-580.

  6. Barber MO. Papel del desbalance glomérulo tubular con preponderancia tubular en la patogénesis de la hipertensión arterial. [Tesis doctoral]. Ciudad de La Habana: ICBP Victoria de Girón; 2007.

  7. Hipertensión arterial. Guía para la prevención, diagnóstico y tratamiento/ Comisión Nacional Técnica Asesora del Programa de Hipertensión arterial. La Habana: Editorial Ciencias Médicas; 2008; 36-38.

  8. Canessa ML, Morgan K, Semplicini A. Genetic differences in lithium-sodium exchange and regulation of the sodium-hydrogen exchanger in essential hypertension. J Cardiovasc Pharmacol. 1988; 12 (3): 92-98.

  9. Schwartz GJ, Haycock GB, Edelman CM y Spitzer A. A simple estimate of glomerular filtration rate in children derived form body lenght and plasma creatinine. Pediatrics. 1976; 58:259-263.

  10. Glorioso N. Endogenous lithium clearance.Journal. 2007;( 8): 1497-1509.

  11. Mendoza C. Importancia ético-científica de los protocolos sobre las investigaciones en seres humanos. Med.leg.Costa Rica [revista en la Internet]. 2003 Mar 20(1): 37-42. [Citado 2013 Mar 28]. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409- 00152003000100005&lng=es

  12. Luyckx VA, Brenner BM. The Clinical Importance of Nephron Mass. J. Am. Soc. Nephrol. 2010; 21(6): 898-910.

  13. Fong D, Denton KM, Moritz KM, Evans R, et al. Compensatory responses to nephron deficiency: adaptive or maladaptive. Nephrology. 2014;(19): 119-128.

  14. Mañalich R, Reyes L, Herrera M, Melendi C, Fundora I. Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int. 2000;58(2):770.

  15. Lurbe E, Redón J, Tacons J, Torró I, Álvarez V. Current and birth weight exert independent influences on nocturnal pressure-natriuresis relationships in normotensive children. Hypertension. 1998; 31: 546-551

  16. Cleper R. Mechanisms of compensatory renal growth. Pediatr Endocrinol 2013; (10):152-63.

  17. Li Yang, Patrick K Leong, Jennifer O Chen, Nilem Patel, Sarah Ft, et al. Acute hypertension provoques internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2001;(20): 730.

  18. Chong E. and Yosypiv IV. "Developmental Programming of Hypertension and Kidney Disease," International Journal of Nephrology, vol. 2012, Article ID 760580, 15 pages, 2012. Disponible en: http://www.hindawi.com/journals/ijn/2012/760580/

  19. Paixa AD, Alexander BT. How the Kidney Is Impacted by the Perinatal Maternal Environment to Develop Hypertension. Biology of reproduction. 2013; 89 (6):144-10.

  20. Peco-Antic A, Paripovic D, Kotur-Stevuljevic J, Stefanovic A, Scekic G, Milosevski. Renal functional reserve in children with apparently normal congenital solitary functioning kidney. Clinical Biochemistry. 2012;45:1125-1268.




2020     |     www.medigraphic.com