Revista Mexicana de Patología Clínica y Medicina de Laboratorio

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Revista Mexicana de Patología Clínica y Medicina de Laboratorio >Year 2016, Issue 2

García-González R, Cervantes-García E, Reyes-Torres A
Tuberculosis, a challenge of the XXI century
Rev Mex Patol Clin Med Lab 2016; 63 (2)

Language: Español
References: 49
Page: 91-99
PDF: 288.11 Kb.

Full text


Tuberculosis is a worldwide public health problem that constitutes one of the principal causes of morbidity and mortality in human beings. Since the 1993 declaration, this disease is considered a worldwide emergency and it is considered as one of the great challenges of the XXI century, since the goals set for the year 2015 (the millennium development goal) were not achieved and it is a causal agent that infects one third of the population worldwide. Mycobacterium tuberculosis is a bacteria that carries multiple virulence factors, most of which are located in its cell wall. These habilitate it to penetrate cells, to multiply intracellularly, to endure within the organism, and to evade both the specific and inespecific immune response of the host. Moreover, the bacteria can remain latent and then reactivate in spite of the late hipersensibility that the host develops as a defense mechanism to erradicate it. All these factors lead to an imbalance of the host-parasite relation and have contributed to the failure of all the efforts made to control the disease. Nevertheless, this has also stimulated the development of procedures directed to have an effective and timely diagnosis.

Key words: Primary and post-primary tuberculosis, acid alcohol resistant bacillus, micolic acid, microscopic morphology.


  1. Tenover FC, Crawford JT, Huebner RE, Geiter LJ, Horsburgh CR Jr, Good RC. The resurgence of tuberculosis: is your laboratory ready. J Clin Microbiol. 1993; 31 (4): 767-770.

  2. Lemassu A, Ortalo-Magné A, Bardou F, Silve G, Laneélle MA, Daffé M. Extracellular and surface-exposed polysaccharides of non-tuberculous mycobacteria. Microbiology. 1996; 142: 1513-1520.

  3. Daniel TM. The history of tuberculosis. Respir Med. 2006; 100: 1862-1870.

  4. Cruz-Anleu ID, Velásquez-Serrato JR. Tuberculosis infantil. ¿Cómo diagnosticarla? Arch Argent Pediatr. 2012; 110 (2): 144-151.

  5. Sudre P, ten Dam G, Kochi A. Tuberculosis: a global overview of the situation today. Bull World Health Organ. 1992; 70 (2): 149-159.

  6. Schaaf SH, Geldenduys A, Gie RP, Cotton MF. Culture-positive tuberculosis in human immunodeficiency virus type 1-infected children. Pediatr Infect Dis. 1998; 17: 599-604.

  7. Chin PD, Crane CM, Diul MY, Sum SJ, Agraz R, Taylor S et al. Spread of Mycobacterium tuberculosis in a community implementing recommended elements of tuberculosis control. JAMA. 2000; 283: 2968-2974.

  8. Organización Panamericana de la Salud. Manual para el diagnóstico bacteriológico de la tuberculosis: normas y guía técnica. Parte I. Baciloscopia. OPS; 2008.

  9. Corbett EL, Watt CJ, Walker N, Maher D, Williams BG et al. The growing burden of tuberculosis. Arch Intern Med. 2003; 163: 1009-1021.

  10. Global tuberculosis report 2014. France: World Health Organization; 2014.

  11. Farga V, Caminero JA. Tuberculosis. 3a ed. Santiago de Chile: Publicaciones Mediterráneo; 2012.

  12. Riechman LB. Defending the public’s health against tuberculosis. JAMA. 1997; 278: 865-867.

  13. Marks J. Notes on the ziehl-neelsen staining of sputum. Tubercle. 1974; 55: 241-244.

  14. McNeil MR, Besra GS, Brennan PJ. Chemistry if the micobacterial cell wall. In: Rom WM, Garay SM (Ed). Tuberculosis. Boston: Little, Brown and Company; 1993. pp. 171-185.

  15. Dannenberg AM. Pathophysiology: basic aspect. In: Schlossberg D (Ed). Tuberculosis and nontuberculous mycobacterial infections. 4th edition. Philadelphia, Pennsylvania: WB Saunders Company; 1999. pp. 17-47.

  16. Cernoch PL, Enns PK, Saubolle MA, Wallace Jr RL. Laboratory diagnosis of the mycobacterioses. Cumitech 16: ASM Press; 1994.

  17. Kaufmann SHE. How can immunology contribute to the control of tuberculosis. Nat Rev Immunol. 2001; 1: 20-30.

  18. Cho SN, Brennan PJ. Tuberculosis: diagnostics. Tuberculosis. 2007; 87: S14-S17.

  19. Hmama Z, Peña-Díaz S, Joseph S, Av-Gay Y. Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis. Immunol Rev. 2015; 264: 220-232.

  20. Gorocica P, Jiménez-Martínez MC, Garfias Y, Sada I, Lascurain R. Componentes glicosilados de la envoltura de Mycobacterium tuberculosis que intervienen en la patogénesis de la tuberculosis. Rev Inst Nal Enf Resp Mex. 2005; 18: 142-153.

  21. Vergne I, Daffé M. Interaction o mycobacterial glycolipids with host cell. Front Biosci. 1998; 3: 865-876.

  22. González-Ruíz C, Reyes-Cortés R. Capítulo10. Transportando hierro a través de la superficie bacteriana. En: De la Garza-Amaya M, Vaca-Pacheco S (editores). La lucha por el hierro patógenos vs hospedero. México, D.F.: Cinvestav; 2010.

  23. Starke JR. Transmission of Mycobacterium tuberculosis to and from children and adolescents. Semin Pediatr Infect Dis. 2001; 12: 115-123.

  24. Arnez-Durán RA, Ayllón-Anzaldo LA, Castro-Soto R, Lozano-Beltrán D. El método MODS, una alternativa para el diagnóstico de la tuberculosis y la detección de cepas multirresistentes. Rev Cient Med. 2010; 13 (2): 81.

  25. Law SD, Zumla AI. Tuberculosis. Lancet. 2011; 378: 57-72.

  26. Maulén NP. Factores de virulencia de Mycobacterium tuberculosis. Rev Med Chile. 2011; 139: 1605-1610.

  27. Cardona PJ, Ausina V. Histopatología de la tuberculosis. Aproximación de la evolución de las lesiones pulmonares en modelos experimentales inducidos mediante aerosol. Arch Bronconeumol. 2000; 36: 645-650.

  28. Co DO, Hogan LH, Kim SI, Sandor M. Mycobacterial granulomas: keys to a long-lasting host-pathogen relationship. Clin Immunol. 2004; 113: 130-136.

  29. Ehrt S, Rhee K, Schnappinger D. Mycobacterial genes essential for the pathogen’s survival in the host. Immunol Rev. 2015; 264: 319-326.

  30. Marais BJ, Gie RP, Obihara CC, Hesseling AC, Schaaf HS, Beyers N. Well defined symptoms are of value in the diagnosis of childhood pulmonary tuberculosis. Arch Dis Child. 2005; 90: 1162-1165.

  31. Moreno-Pérez D, Martín AA, Gómez NA, Baquero-Artigao F et al. Diagnóstico de la tuberculosis en la edad pediátrica. Documento de consenso de la Sociedad Española de Infectología Pediátrica (SEIP) y la Sociedad Española de Infectología Pediátrica (SENP). An Pediatr (Barc). 2010; 73 (3): 143e1-143e14.

  32. Guidance for National Tuberculosis Programmes on the management of tuberculosis in children. WHOHTM/TB/2006.371.

  33. Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann. Pediatric tuberculosis. Lancet Infect Dis. 2008; 8: 498-510.

  34. García GR, Lara HA, Nájera GMC, Arzate BP. Detección de Mycobacterium tuberculosis, con el empleo de dos sistemas de cultivo y su confirmación con la reacción en cadena de la polimerasa. Rev Enf Infec Ped. 1999; 12: 323-328.

  35. Saltini C. Chemotherapy and diagnosis of tuberculosis. Respir Med. 2006; 100: 2085-2097.

  36. Andersen P, Munk ME, Pollock JM, Doherty TM. Specific immune-based diagnosis of tuberculosis. Lancet. 2000; 356: 1099-1104.

  37. Lighter J, Rigaud M. Diagnosing childhood tuberculosis. Curr Peobl Pediatr Adolesc Health Care. 2009; 39: 61-88.

  38. Drobniewski FA, Caws M, Gibson A, Young D. Modern laboratory diagnosis of tuberculosis. Lancet Infect Dis. 2003; 3 (3): 141-147.

  39. Wilson MD. Rapid diagnosis of Mycobacterium tuberculosis infection and drug susceptibility testing. Arch Pathol Lab Med. 2013; 137: 812-819.

  40. Agudelo CA, Builes NL, Hernández M, Robledo J. Nuevos métodos para el diagnóstico de la tuberculosis. Iatreia. 2008; 21: 321-332.

  41. Moore DAJ, Evans CAW, Gilman RH, Caviedes L, Coronel J, Vivar A et al. Microscopic-observation drug susceptibility assays for the diagnosis of TB. N Engl J Med. 2006; 355: 1539-1550.

  42. Pai M, Kalanteri S, Dheda K. New tools and emerging technologies for the diagnosis of tuberculosis: part II. Active tuberculosis and drug resistance. Expert Rev Mol Diagn. 2006; 6: 423-432.

  43. Minion J, Leung E, Menzies D, Pai M. Microscopic-observation drug susceptibility and thin layer agar assays for the detection of drug resistant tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2010; 10: 688-698.

  44. Martin A, Palomino JC. Procedure manual. Thin layer agar (TLA) microcolony detection. Antwerp, Belgium: Institute of Tropical Medicine, Mycobacteriology Unit; 2009.

  45. Kalantri S, Pai M, Pascopella L, Riley L, Reingold A. Bacteriophage based test for the detection of Mycobacterium tuberculosis in clinical specimens: a systematic review and meta-analysis. BMC Infect Dis. 2005; 5: 59.

  46. Nahid P, Pai M, Hopewell PC. Advances in the diagnosis and treatment of tuberculosis. Proc Am Thorac Soc. 2006; 3: 103-110.

  47. Carvalho WS, Miranda SS, Pesquero JL, Gomes MA. Diagnóstico de resistência do Mycobacterium tuberculosis á rifampicina utilizando-se da reação em cadeia da polimerase. Brazilian Journal of Pharmaceutical Sciences. 2007; 43: 31-36.

  48. Thierry D, Cave MD, Eisenach KD, Crawford JT, Bates JH, Gicquel B et al. IS6110, an IS-like element of Mycobacterium tuberculosis complex. Nucleic Acids Res. 1990; 18 (1): 188.

  49. Pai M, Riley LW, Colford JM. Interferon γ assays in the immunodiagnostics of tuberculosis: a systematic review. Lancet Infect Dis. 2004; 4: 761-776.

>Journals >Revista Mexicana de Patología Clínica y Medicina de Laboratorio >Year 2016, Issue 2

· Journal Index 
· Links 

Copyright 2019