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2016, Number 2

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Rev Mex Pediatr 2016; 83 (2)

Lactobacillus reuteri DSM 17938 in preventing necrotizing enterocolitis in preterm newborns. Pilot study of efficacy and safety

Hernández-Enríquez NP, Rosas-Sumano AB, Monzoy-Ventre MA, Galicia-Flores L

Language: Spanish
References: 37
Page: 37-43
PDF size: 307.44 Kb.


ABSTRACT

Necrotizing enterocolitis is the most common and serious intestinal disorder that occurs in newborns, mainly in preterm infants with very low birth weight (less than 1,500 g weight with gestational age of less than 34 weeks gestation). Objective: To evaluate the effectiveness of the use of the probiotic Lactobacillus reuteri 17938 DMS, to reduce the incidence of necrotizing enterocolitis in infants with very low birth weight. Patients and methods: It was a clinical trial, controlled, randomized. There were selected infants with very low birth weight which were randomly divided into 2 groups. Group A (study group) received Lactobacillus reuteri 5 drops, equivalent to 100 million colony forming units (1 × 108 CFU) daily, whether they were newborns with weight greater than 1,000 to 1,500 g. In the case of newborns with weight less than 1,000 g them 3 drops were administered Lactobacillus reuteri (60 million CFU) daily. Group B (control group) received no probiotic. Probiotic administration was for 20 days, with mixed feed in both groups. The diagnosis and classification of necrotizing enterocolitis were made of three neonatologists, who knew the group allocation. Results: 106 patients were eligible, 44 newborns were admitted to the study. The incidence of suspected necrotizing enterocolitis (1 of 24 versus 10 of 20) was significantly lower in the study group : OR 23.0 (95%CI 2.58 - 204.60). With a number needed to treat of 11. Conclusion: Supplementation with Lactobacillus reuteri DSM 17938 is effective in preventing necrotizing enterocolitis.


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