2016, Number 2
PDF size: 334.54 Kb.
ABSTRACTPorocarcinoma is a malignant proliferation originated from intraepidermal portion of eccrine glands. Its frequency is rare as it represents less than 1% of cutaneous tumors.
Our objective is to report the clinical-histophalogical characteristics of all the 24 cases registered in the Dermatopathology Unit from Hospital General de Mexico “Dr. Eduardo Liceaga”, from January 1975 to December 2013, and to measure the semi-quantitative Ki-67 protein expression, a well known proliferation index and to correlate its expression with the clinical outcome in each patient.
We found porocarcinoma more frequently in women (ratio 2:1), with a mean age 59.7 (range 18 to 87 years). The most frequent localization on the lower limbs, with a predominant nodular morphology and a mean clinical size of 2.3 cm. Histopathological characteristics showed that most of the cases were invasive 23, (95.8%), with duct formation 18 (75%) and associated to a benign eccrine poroma 11 (45%). Mean histological depth, 3.46 mm and all biopsies had immunohistochemistry epithelial membrane antigen and carcinoembrionary antigen with a variable expression, as Ki-67 protein expression, had a wide range from 5 to 80% of total lesion and statistical analysis showed a significant relationship between Ki-67 expression and local recurrence, invasion, metastasis and death due to porocarcinoma.
We conclude that the high expression of Ki-67 proliferation index is a poor prognostic factor in patients with porocarcinoma as it represents a higher probability of local recurrence, invasion, metastasis and mortality. So we proposed the routinary determination of this proliferation index in order to obtain a complete histological and immunohistochemical evaluation of porocarcinoma.
Requena, L., Kutzner, H., Hurt, M.A., Santa Cruz, D.J. y Meheregan, A.H., “Malignant tumours with apocrine and eccrine differentiation”, en LeBoit, P., Burg, G., Weedon, D. y Sarasin, A. (eds.), Pathology and genetics. Skin tumours. World health organization classification of tumours, Lyon, World Health Organization, 2006: 128-130.