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2016, Number 2

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Rev Clin Esc Med 2016; 6 (2)

Patogénesis de la enfermedad por virus del dengue. Revisión de la literatura

Beita JJ, Salazar AN, Valverde GM

Language: Spanish
References: 19
Page: 11-17
PDF size: 600.39 Kb.


ABSTRACT

Dengue virus (DENV) belongs to the Flaviviridae family, it is transmitted by mosquitos of the Aedes genus, which has a worldwide distribution; this is the reason why it represents a public health issue. It is a RNA virus, with tropism for multiple human cells, with a well-established and studied viral cycle. The RNA encodes three structural and seven nonstructural proteins, each one of these with a different implication in the pathogenesis. DENV has five different serotypes, but only four are medically relevant. The disease can be asymptomatic or symptomatic. According to the World Health Organization (WHO), symptomatic disease is classified in Dengue and Severe Dengue, the first one has an auto limited presentation, and the second could have clinical consequences that range from mild capillary leak to third-space fluid shift, hemorrhagic phenomena, gastrointestinal and neurological alterations and hemodynamic instability. A primoinfection immune response has been elucidated, which usually is less severe than a second infection caused by a heterologous serotype, where an antibody-dependent enhancement amplifies the inflammatory response that could eventually cause a more severe clinical presentation.


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