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2016, Number 2

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Rev Clin Esc Med 2016; 6 (2)

Cirugía bariátrica como opción de tratamiento de la diabetes mellitus tipo 2. Fundamentos fisiopatológicos

Leitón CA, Vargas LV
Full text How to cite this article

Language: Spanish
References: 12
Page: 11-23
PDF size: 1186.11 Kb.


Key words:

Bariatric, Bypass, GLP-1, GIP, PYY, Insulin, Adipokines.

ABSTRACT

Currently type 2 diabetes mellitus reached epidemic levels around the world affecting 285 million worldwide. DM-2 is a disease with a complex pathophysiology, which continues in constantly investigation, this disease represents one of the most challenging pathologies for medical treatment, requiring constant monitoring with comprehensive regulation of medication to prevent progression to serious sequelae. Until recently all the research dedicated to the treatment of this condition was aimed at a combination treatment between changes in lifestyles and medications with a variety of mechanisms of action. Recently, weight loss surgery has been established as an alternative treatment for obese patients with type 2 diabetes, nowadays there are many publications that demonstrate their effectiveness in both the short and long term. The aim of this article is to review the basic concepts of bariatric surgery, history, types of procedures, indications and contraindications and analyze updated publications that demonstrate positive results in diabetes management with surgery, as well as expose the latest evidence on the pathophysiological effects that explain the results published regarding the surgical management of diabetes, which are still ongoing research because they include multiple mechanisms that are not explained only by weight loss.


REFERENCES

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  2. Dolores M Pujante P López A Ibañez M Hernández A Hernández AB. Review: Surgical Treatment of Type 2 Diabetes. Pharmacology & Pharmacy. 2014; 5: 24-29

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  9. Zhang C Yuan Y Qiu C Zhang W. A Metaanalysis of 2-Year Effect After Surgery: Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy for Morbid Obesity and Diabetes Mellitus. Obes Surg. 2014; 24(9): 1528-1535.

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Rev Clin Esc Med. 2016;6