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Revista Mexicana de Neurociencia

Academia Mexicana de Neurología, A.C.
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2005, Number 2

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Rev Mex Neuroci 2005; 6 (2)

Medial holoprosencephaly. Presentation of three cases and neuroimageological correlation.

Camelio S, Vásconez JV, Campos C
Full text How to cite this article

Language: Spanish
References: 6
Page: 186-188
PDF size: 174.65 Kb.


Key words:

middle holoprosencephaly, cerebral hemispheres, magnetic resonance.

ABSTRACT

The pathology of the middle interhemisferic variant of the Holoprosencephaly (HPC) is an abnormal connection between cerebral hemispheres in the medium line of the anterior or parietal frontal regions that affects children and provoking them mental retardation, spastic quadriparesis, athetoidal movements, endocrinal upsets and epilepsy. ZIC2 gene mutations are considered determinant factors in the formation of neural plaque roof and interhemispherical scissura. We expose and study the encephalon’s magnetic resonance in three children to specify the appearance of the middle interhemisferic variant of HPC its possible reasons for malformation and thus to make sure about prognosis for their future neurological rehabilitation.


REFERENCES

  1. Takanashi J, Barkovich AJ, Cleegg NJ, Delgado M. Middle interhemisferic variant of holoprosencephaly associated with diffuse polymicrogiria. AJNR 2003, 24: 394-7.

  2. Barkovich AJ, Simon EM, Cleegg NJ, Kinsman SL, Hahn JS. Analysis of the cerebral cortex in holoprosencephaly with attention to the sylvian fissures. AJNR 2002, 23: 143-50.

  3. Lewis A, Simon E, Barkovich AJ, Cleegg NJ, Delgado MR, Levey E, Hahn JS. Middle interhemispheric variant of holoprosencephaly: A distinct cliniconeuroradiologic subtype. Neurology 2002, 59: 1860-5.

  4. Simon E, Hevner R, Pinter J, Cleegg N, Delgado M, Kinsman S, Han J. Barkovich J. The middle interhemispheric variant of holoprosencephaly. AJNR 2002; 23: 151-5.

  5. Kinsman SL. White matter imaging in holoprosencephaly in children. Current opinion in Neurology 2004; 17: 115-9.

  6. Simon EM, Hevner R, Pinter JD. et al. Assesment of the Deep Gray Nuclei in Holoprosencephaly. AJNR 2000; 21: 1955-61.




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Rev Mex Neuroci. 2005;6