medigraphic.com
SPANISH

Revista Clínica de la Escuela de Medicina de la Universidad de Costa Rica

  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2016, Number 3

<< Back Next >>

Rev Clin Esc Med 2016; 6 (3)

Lupus Eritematoso Sistémico con Anticuerpos Antinucleares Negativos: Revisión de Tema

Vindas AG, Salazar AN, Beita JJ, Valverde GM
Full text How to cite this article

Language: Spanish
References: 18
Page: 11-17
PDF size: 437.80 Kb.


Key words:

Antinuclear antibodies, Lupus, ANA negative, Antinucleosome antibodies.

ABSTRACT

The ANA-negative lupus is a rare variant of the spectrum of the lupus systemic erythematosus,which was first described in 1976with an incidence of 5%of the SLE population. In nowadays the real incidence is not known. A lot of papers had being done with the purpose to describe the clinical manifestations, the evolution and pathophysiology of this disease, but there are still a lot of doubts that no allowed to make solid conclusion about it.


REFERENCES

  1. Tsokos G. Systemic Lupus Erythematosus. N Engl J Med. 2011;365:2110-21.

  2. Maddison P, Provost T, Reichlin M. Sero-logical findings in patients with “ANA negative” systemic lupus erythematosus. Medicine 1981;60:87-94.

  3. Hepburn A, Charles P. Antinuclear factor. Rheumatology 2002;41:343-345.

  4. Editors. Antinuclear antibodies: cause of disease or caused by disease? Rheumato-logy 2000;39:581-584.

  5. Cross L, Aslam A, Misbah S. Antinuclear antibody-negative lupus as a distinct diag-nostic entity-does it no longer exist? Q J Med 2004;97:303-308.

  6. Burlingame R, Cervera R. Anti-chromatin (anti-nucleosome) autoantibodies. Auto-immunity Reviews 2002;1:321–328.

  7. Koutouzov S, Jeronimo A, Campos H, et al. Nucleosomes in the pathogenesis of sys-temic lupus erythematosus. Rheum Dis Clin N Am 2004;30:529–558.

  8. Pirkle J, Freedman B, Fogo A. Immune complex disease with a Lupus-like pattern of deposition in an antinuclear antibody–negative patient. Am J Kidney Dis 2013;62:159-164.

  9. Mevorach D. The role of death-associated molecular patterns in the pathogenesis of systemic lupus erythematosus. Rheum Dis Clin N Am 2004;30:487–504.

  10. Builes C, Durango I, Velásquez G. Lupus eritematoso sistémico con anticuerpos an-tinucleares negativos y anemia hemolítica. Acta Med Colomb 2010;35: 79-182.

  11. Reichlin M. ANA negative systemic lupus erythematosus sera revisited serologically. Lupus 2000;9:116-119

  12. Davis J, Moder K, Homburger H, et al. Clinical features of 39 patients with anti-bodies to extractable nuclear antigens de-spite negative antinuclear antibodies. Medicine 2005;84:208–217.

  13. Tozzoli R, Bizzaro N, Tonutti E, et al. Guidelines for the laboratory use of auto- antibody tests in the diagnosis and moni-toring of autoinmune Rheumatic Diseases. Am J Clin Pathol 2002;117:316-324.

  14. Pham B, Albarede S, Guyard A, et al. Im-pact of external quality assessment on an-tinuclear antibody detection performance. Lupus 2005;14:113–119.

  15. Arbuckle M, McClain M, Rubertone M, et al. Development of autoantibodies before the clinical onset of systemic lupus ery-thematosus. N Engl J Med 2003;349:1526-33.

  16. Ippolito A, Wallace D, Gladman D, et al. Autoantibodies in systemic lupus erythe-matosus: comparison of historical and current assessment of seropositivity. Lupus 2011;20:250–255.

  17. Song L, Ding F, Liu H, et al. Analysis of 15 patients with systemic lupus erythema-tosus manifesting with negative immuno-fluorescence anti-nuclear antibodies after treatment. Lupus 2012;21:919–924.

  18. Locham K, Singh J, Garg R. ANA lupus negative erythematosus. Indian Pediatrics 2000;37:540-542.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Clin Esc Med. 2016;6