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2016, Number 619

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Rev Med Cos Cen 2016; 73 (619)

Enfermedad de Crohn

Villegas SLR, Marchena VEA, García GLA, Trejos HJ, González CD, Poveda RCA
Full text How to cite this article

Language: Spanish
References: 22
Page: 423-428
PDF size: 494.05 Kb.


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ABSTRACT

Crohn’s disease is a complex clinical entity, chronic and unpredictable evolution, which is considered within the inflammatory conditions that involves the terminal ileum more often but can make other sectors of the digestive tract (jejunum, colon, stomach) and which has general effects on different systems of the body. Every time are clarifying aspects of its pathogenesis; is considered probable involvement of environmental triggers of undetermined nature (snuff, infections, dietary components, etc.). Thus, in genetically predisposed patients, intestinal mucosa would begin and perpetuate immune complex, exaggerated and uncontrolled response, primarily mediated by T lymphocytes against luminal antigens, including bacterial enteric microflora. It occurs as a chronic inflammatory process that leads to a thickening of all layers of the intestine. The terminal ileum as the only location is at 30% but no injuries often ileocecal valve and colon and coming right forms of presentation with ileal constitute 70% commitment. Less frequently can compromise in other areas of the small intestine jejunum and ileum. The lesions may be single or multiple separated by areas unchanged.


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Rev Med Cos Cen. 2016;73