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2016, Number 1

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RCAN 2016; 26 (1)

Urine excretion of urea nitrogen estimated from urea-creatinine index adjusted for body weight

García AL, Santana PS

Language: Spanish
References: 16
Page: 84-92
PDF size: 446.43 Kb.


ABSTRACT

Rationale: Excretion of urine urea nitrogen (UUN) might be estimated from the Urea- Creatinine index (UCI) as calculated from a morning urine sample after adjusting for subject’s height. Body weight could also be used as the normalizer of the UCI. Objective: To assess the analytical and diagnostic usefulness of body weight as normalizer of the UCI in the UUN predictive equation. Material and method: UCI was calculated with urea and creatinine concentrations as present in a morning urine sample obtained from 154 patients (Males: 37.7%; Ages ≥ 60 years: 31.1%) assisted at the “Hermanos Ameijeiras” Clinical Surgical Hospital (Havana City, Cuba) between October 2013 and October 2014. UUN excretion was predicted from UCI by means of a mathematical equation incorporating body weight as anthropometric normalizer. Accuracy of UUN measurement in morning urine samples was compared with that of the values obtained with 24 hours collections. Results: UUN predicted from UCI was equivalent with that observed in 24 hours collections: Predicted: 8.53 ± 4.70 g.24 hours-1 vs. Observed: 8.52 ± 4.65 g.24 hours-1 (t = -0.022; p › 0.05; test for paired means). Frequency of UUN values › 5 g.24 hours-1 was independent from the method used for measuring UUN: Predicted: 78.6% vs. Observed: 76.6% (p › 0.05; McNemar’s test for paired observations). Conclusions: Measurement of UNN excretion from UCI adjusted by body weight is a valid option for assessing nitrogen metabolism in the hospitalized subject.


REFERENCES

  1. García Arévalo L, Santana Porbén S. Excreción urinaria de nitrógeno ureico estimada del índice urea-creatinina como se determina en muestras únicas de orina. RCAN Rev Cubana Aliment Nutr 2015; 25:314-26.

  2. Salabarría González JR, Santana Porbén S, Liriano Ricabal MR. Excreción urinaria de una sustancia predicha del índice de excreción. Rev Latinoam Patol Clín Med Lab 2015;62:120-7.

  3. Santana Porbén S. Valores locales de referencia para la excreción urinaria de creatinina: Una actualización. RCAN Rev Cubana Aliment Nutr 2014;24: 220-30.

  4. Myers VC, Fine MI. The creatine content of muscle under normal conditions: Its relation to the urinary creatinine. J Biol Chem 1913;14:9-26.

  5. Burger M. The meaning of creatinine coefficient for the quantitative measurement of muscle mass and body composition. Creatine and creatinine excretion: Relationship to muscle mass. Z Gesamte Exp Med 1919;9:361-99.

  6. Forbes GB, Bruining GJ. Urinary creatinine excretion and lean body mass. Am J Clin Nutr 1976;29:1359-66.

  7. Mitsiopoulos N, Baumgartner RN, Heymsfield SB, Lyons W, Gallagher D, Ross R. Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol 1998;85: 115-22.

  8. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.

  9. Bartels H, Cikes M. Ueber Chromogene der Kreatininbestimmung nach Jaffé [Chromogens in the creatinine determination of Jaffé]. Clin Chim Acta 1969;26:1-10 [Article originally published in German].

  10. Gutmann I, Bergmeyer HU. Determination of urea with glutamate dehydrogenase as indicator enzyme. En: Methods of enzymatic analysis [Editor: Bergmeyer HU]. Volume 4. Academic Press. New York: 1974. pp 1794-1798.

  11. Santana Porbén S. Evaluación bioquímica del estado nutricional del paciente hospitalizado. Nutrición Clínica [México] 2003;6:293-311.

  12. Cronberg S, Nordstrom L, Ringberg H. Prediction of creatinine clearance by several methods in patients with severe infections. Eur J Clin Pharmacol 1992; 42(2):193-5.

  13. Santana Porbén S, Martínez Canalejo H. Manual de procedimientos bioestadísticos. EAE Editorial Académica Española. Segunda edición. Madrid: 2012. ISBN-13: 9783659059629. ISBN-10: 3659059625.

  14. Walser M. Creatinine excretion as a measure of protein nutrition in adults of varying age. JPEN J Parenter Enteral Nutr 1987;11(Suppl):73S-85S.

  15. Acosta Jiménez SM, Rodríguez Suárez A, Díaz Sánchez ME. La obesidad en Cuba. Una mirada a su evolución en diferentes grupos poblacionales. RCAN Rev Cubana Aliment Nutr 2013;23: 297-308.

  16. Martinuzzi ALN, Alcántara S, Corbal A, Di Leo ME, Guillot A, Palaoro A; et al. Nitrógeno ureico urinario como indicador del metabolismo proteico en el paciente crítico. RCAN Rev Cubana Aliment Nutr 2011;21:224-35.




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