medigraphic.com

2015, Number 3-4

<< Back

Rev Hosp Jua Mex 2015; 82 (3-4)

Paraganglioma gangliocítico del ámpula de Vater, resección endoscópica

Cruz-Reyes JM, Pérez-Corona T, Porras-Escorcia O, Altamirano-Arcos CA, Vargas-Mejía JL, Godínez-Franco LS

Language: Spanish
References: 13
Page: 173-176
PDF size: 171.85 Kb.


ABSTRACT

Background. A paraganglioma is a rare type of neuroendocrine tumor, derived from extra-adrenal chromaffin cells of the paraganglia, this structure is derived of neural crest which migrate to different locations of the body, this explains the distribution of these tumors, carotid sinus paraganglioma are the most frequent location, and the duodenum occurrence is extremely rare and 90 % are located in the ampulla of Vater. We present a case in order to review current concepts. Clinical case. We present a case of a 77 year-old female seen in the consult with postprandial fullness of 10 months of evolution to oral intolerance, associated with melenic stools. A penendoscopy revelead a pendunculated submucosal 2 cm tumor located in the ampulla of Vater, corfirmed with endoscopic ultrasonography. An endoscopic resection was performed. The histopathology report was of a gangliocytic paraganglioma confirmed by immunohistochemistry. Conclusions. This entity is extremely rare, knowledge is important to include it in the differential diagnosis of periampullary tumors.


REFERENCES

  1. Rebolledo Pulido V, Gubaira J, Perfetti W, Verdecchia D, González R, Mora E. Tumores del sistema paraganglionar. Rev Venez Oncol 2006; 18(3): 177-83.

  2. Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, et al. Endocrine Society. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014; 99(6): 1915-42.

  3. Plouin PF, Fitzgerald P, Rich T, Ayala-Ramirez M, Perrier ND, Baudin E, et al. Metastatic pheochromocytoma and paraganglioma: focus on therapeutics. Horm Metab Res 2012; 44: 390-9.

  4. Yoo C. Gangliocytic paraganglioma of the duodenum. J Korean Surg Soc 2007; 73: 68-71.

  5. Okubo Y, Wakayama M, Nemoto T, Kitahara K, Nakayama H, Shibuya K, et al. Literature survey on epidemiology and pathology of gangliocytic paraganglioma. BMC Cancer 2011; 11: 187.

  6. Perrone T, Sibley RK, Rosai J. Duodenal gangliocytic paraganglioma. An immunohistochemical and ultrastructural study and a hypothesis concerning its origin. Am J Surg Pathol 1985; 9: 31-41.

  7. Loftus TJ, Kresak JL, Gonzalo DH, Sarosi GA, Behrns KE. Duodenal gangliocytic paraganglioma: A case report and literature review. Int J Surg Case Rep 2015; 8: 5-8.

  8. Loew BJ, Lukens FJ, Navarro F, Roy M, Mattia A, Howell DA. Successful endoscopic resection of a gangliocytic paraganglioma of the minor papilla in a patient with pancreas divisum and pancreatitis (with video). Gastrointest Endosc 2007; 65(3): 547-50.

  9. van Berkel A, Lenders JW, Timmers HJ. Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma. Eur J Endocrinol 2014; 170(3): R109-R119.

  10. Shi H, Han J, Liu N, Ye Z, Li Z, Li Z, et al. A gangliocytic partially glandular paraganglioma with lymph node metastasis. Diagn Pathol 2014; 9: 63.

  11. Kwon J, Lee SE, Kang MJ, Jang J-Y, Kim S-W. A case of gangliocytic paraganglioma in the ampulla of Vater. World J Surg Oncol 2010; 8: 42.

  12. Lau N, Hari D, French S. SOX10 expression in a gangliocytic paraganglioma – a case report. Exp Mol Pathol 2015; 98(1): 99-101.

  13. Dookhan DB, Miettinen M, Finkel G, Gibas Z. Recurrent duodenal gangliocytic paraganglioma with lymph node metastases. Histopathology 1993; 22(4): 399-401.




2020     |     www.medigraphic.com