2016, Number S2
Gac Med Mex 2016; 152 (S2)
Influence of Gender on the Clinical Presentation and Associated Diseases in Adults with Celiac Disease
Rubio-Tapia A, Jansson-Knodell CL, Rahim MW, See JA, Murray JA
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Celiac disease is diagnosed predominantly in women. Objectives:
We investigated the influence of gender
on (i) age at diagnosis, (ii) clinical manifestations, and (iii) prevalence of associated disorders. Methods: Clinical data were
abstracted from the medical record of adults with biopsy-proven celiac disease. Results:
The cohort consisted of 385 patients
(women, 71%). Women were diagnosed at a younger age (women, 46.1 years; men, 52.6 years; p = 0.001). The prevalence
of the following symptoms was higher in women: nausea/vomiting (women, 31%; men, 16%; p = 0.001), constipation (women,
21%; men, 10%; p = 0.007), and malaise/fatigue (women, 43%; men, 33%; p = 0.06). Greasy stools were more prevalent in
men (women, 11%; men, 22%; p = 0.006). Autoimmune diseases were observed in 127 (33%) patients with a female to male
ratio of 1.6 (women, 37%; men, 23%; p = 0.006). Depression, osteoporosis, and fibromyalgia predominated in women. Conclusions:
Our findings suggest clinically relevant gender-related differences in celiac disease. These gender differences should
be taken into account when managing adult patients with celiac disease.
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