medigraphic.com
ISSN 0016-3813 (Print)

2016, Number 5

<< Back Next >>

Gac Med Mex 2016; 152 (5)

Gender differences in lipocalin 2 plasmatic levels are correlated with age and the triglyceride/high-density lipoprotein ratio in healthy individuals

De la Chesnaye E, Manuel-Apolinar L, Oviedo-de Anda N, Revilla-Monsalve MC, Islas-Andrade S

Language: English
References: 21
Page: 612-617
PDF size: 113.12 Kb.


ABSTRACT

Introduction: The increment of lipocalin 2, also called neutrophil gelatinase-associated lipocalin, plasmatic levels is associated with cardiometabolic and nefrologic alterations. Nonetheless, there is much controversy about lipocalin 2 plasmatic concentrations among healthy individuals. Aim: The aim of this study was to quantify lipocalin 2 in plasma of healthy men and women and to assess a possible correlation with cardiometabolic risk factors. Methods: Fifty-three subjects (24 men and 29 women) were included. By means of an ELISA, a higher concentration of lipocalin 2 was observed in men than in women (91 ± 9 vs. 57 ± 7 ng/ml). Such difference was statistically significant (p ‹ 0.0001). Results: Lipocalin 2 levels were significantly correlated with body mass index, homeostasis model assessment index-insulin resistance index, triglycerides, high-density lipoprotein, and age. Conclusion: Lipocalin 2 plasmatic concentrations present a gender-specific profile in healthy subjects and its circulating levels appear to be age-dependent and associated with several cardiometabolic risk factors, including the triglycerides/high-density lipoprotein cholesterol ratio, which has proven to be a reliable marker for cardiometabolic risk among the global population.


REFERENCES

  1. Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol. 2015;402:113-9.

  2. Wild S, Roglic G, Green A, Scree R, King H. Global prevalence of diabetes estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53.

  3. Lundsgaard AM, Kiens B. Gender differences in skeletal muscle substrate metabolism-molecular mechanisms and insulin sensitivity. Endocrinology. 2014;5:195.

  4. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115:1111-19.

  5. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444: 860-7.

  6. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821-30.

  7. Luque-Ramírez M, Martínez-García MA, Montes-Nieto R, et al. Sexual dimorphism in adipose tissue function as evidenced by circulating adipokine concentrations in the fasting state and after an oral glucose challenge. Hum Reprod. 2013;28:1908-18.

  8. Makovey J, Naganathan V, Seibel M, Sambrook P. Gender differences in plasma ghrelin and its relations to body composition and bone-an opposite sex twin study. Clin Endocrinol. 2007;66:530-7.

  9. Devarajan P. Neutrophil gelatinase-associated lipocalin: new paths for an old shuttle. Cancer Ther. 2007;5:463-70.

  10. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation an primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993;268:10425-32.

  11. Kjeldsen L, Bainton DF, Sengelov H, Borregaard N. Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood. 1994;83:799-807.

  12. Ronco C. Biomarkers for acute kidney injury: is NGAL ready for clinical use? Crit Care. 2014;18:680.

  13. Marti-Macia C, Tomasa TM, Sancho A, et al. [Analysis of neutrophil gelatinase-associated lipocalin in the critical patient]. Med Intensiva. 2014;38:146-53.

  14. De la Chesnaye E, Manuel-Apolinar L, Zarate A, et al. Lipocalin 2 plasmatic levels are reduced in patients with long-term type 2 diabetes mellitus. Int J Clin Exp Med. 2015;8:2853-9.

  15. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of high Blood Pressure. Arch Intern Med. 1997;157:2413-46.

  16. Thraikill KM, Moreau CS, Cockrell GE. Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus. Endocrine. 2010;37:336-43.

  17. Wang Y, Lam KSL, Kraegen EW, et al. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem. 2007;53:34-41.

  18. Abu-farha M, Dehbi M, Noronha F, et al. Gender differences in ghrelin association with cardiometabolic risk factors in Arab population. Int J Endocrinol. 2014;2014:730472.

  19. Guo H, Zhang Y, Brockman DA, Hahn W, Bernlohr DA, Chen X. Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice. Endocrinology. 2012;153:1183-93.

  20. Fried SK, Greenberg AS. Lipocalin 2: a “sexy” adipokine that regulates 17beta- estradiol and obesity. Endocrinology. 2012;153:1582-4.

  21. Tarjus A, Martínez-Martínez E, Amador C, et al. Neutrophil gelatinase-associated lipocalin, a novel mineralocorticoid biotarget, mediates vascular profibrotic effects of mineralocorticoids. Hypertension. 2015;66:158-66.




2020     |     www.medigraphic.com