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2016, Number 6

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Rev ADM 2016; 73 (6)

Expression of E-cadherin and Langerhans cells in verruca vulgaris and oral papilloma

Cháirez-Atienzo P, Vega-Memíje ME, García-Vázquez FJ, Cuevas-González JC

Language: Spanish
References: 22
Page: 291-296
PDF size: 737.62 Kb.


ABSTRACT

Introduction: Verruca vulgaris and oral papilloma are lesions caused by the human papillomavirus. They can be found on most skin and mucosal surfaces, and their biological behavior is benign. Adhesion proteins such as E-cadherins are responsible for maintaining cell morphology and organization; they decrease the expression in certain potentially cancerous epithelial lesions and promote cell migration and invasion, causing possible metastasis. Langerhans cells are antigen-presenting cells that activate the immune system to protect the body against pathogens or foreign substances. Objective: To determine the degree of expression of E-cadherin and Langerhans cells in verruca vulgaris and oral papilloma. Material and methods: We performed a descriptive and retrospective study involving 16 paraffin-embedded tissue blocks of diagnosed cases of verruca vulgaris and 4 paraffin-embedded tissue blocks identified as oral papilloma. The diagnosis was previously confirmed by hematoxylin and eosin staining. The degree of expression of Langerhans cells and E-Cadherin was determined by immunohistochemistry, while the evaluation was carried out semiquantitatively, with descriptive statistics being performed. Results: The expression of E-cadherin in verruca vulgaris was strong in terms of both quantity and intensity, whereas in the case of oral papilloma it was moderate for both. Langerhans cells showed moderate immunostaining for both intensity and quantity in verruca vulgaris-type lesions, while for oral papilloma, the immunostaining was also mild in both cases. Conclusions: The results suggest that the expression of E-cadherin adhesion proteins does not diminish in verruca vulgaris and oral papilloma, which confirms their benignity. Langerhans cell expression suggests that the skin—which shows a greater presence of these cells—is more reactive than the oral mucosa.


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