Yataco M, Patel T

Language: English
References: 10
Page: 660-661
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Simental-Mendía L, et al. The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women

Non-Alcoholic Fatty Liver Disease (NAFLD) is considered by many to be the hepatic manifestation of metabolic syndrome, the constellation of obesity, impaired glucose tolerance, dyslipidemia and hypertension that has been associated with a higher prevalence of NAFLD and Non-Alcoholic Steatohepatitis (NASH).1 Most patients with NAFLD are asymptomatic, with many of them suspected to have fatty liver disease because of elevated liver function tests or abnormal imaging studies, found during evaluation of other medical complains or routine tests.

REFERENCES

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2. Unger G, Benozzi SF, Perruzza F, Pennacchiotti GL. Triglycerides and glucose index: a useful indicator of insulin resistance. Endocrinol Nutr 2014;61: 533-40.

3. Vasques AC, Novaes FS, de Oliveira Mda S, Souza JR, Yamanaka A, Pareja JC, Tambascia MA, et al. TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study. Diabetes Res Clin Pract 2011;93: e98-e100.

4. Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol 2013;10: 686-90.

5. Fedchuk L, Nascimbeni F, Pais R, Charlotte F, Housset C, Ratziu V. Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease. Aliment Pharmacol Ther [Research Support, Non-U.S. Gov’t] 2014; 40: 1209-22.

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8. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol. [Practice Guideline] 2009; 51: 237-67.

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10. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology 2006; 131: 283-311.