>Annals of Hepatology
>Year 2016, Issue 5
Arab JP, Barrera F, Gallego C, Valderas JP, Uribe S, Tejos C, Serrano C, Huete A, Liberona J, Labbé P, Quiroga T, Benítez C, Irarrázaval P, Riquelme A, Arrese M
High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic patients
Ann Hepatol 2016; 15 (5)
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Background. Patients with type 2 diabetes mellitus (T2DM) are at risk for developing end-stage liver disease due to nonalcoholic
steatohepatitis (NASH), the aggressive form of non-alcoholic fatty liver disease (NAFLD). Data on prevalence of advanced fibrosis
among T2DM patients is scarce. Aim. To evaluate prevalence of steatosis, advanced fibrosis and cirrhosis using non-invasive
methods in T2DM patients. Material and methods. 145 consecutive T2DM patients (› 55 years-old) were prospectively recruited.
Presence of cirrhosis and advanced fibrosis was evaluated by magnetic resonance imaging (MRI) and NAFLD fibrosis score
(NFS) respectively. Exclusion criteria included significant alcohol consumption, markers of viral hepatitis infection or other liver diseases.
Results are expressed in percentage or median (interquartile range). Results. 52.6% of patients were women, the median
age was 60 years old (57-64), mean BMI was 29.6 ± 4.7 kg/m2 and diabetes duration was 7.6 ± 6.9 years. A high prevalence of liver
steatosis (63.9%), advanced fibrosis assessed by NFS (12.8%) and evidence of liver cirrhosis in MRI (6.0%) was observed. In a
multivariate analysis GGT › 82 IU/L (P = 0.004) and no alcohol intake (P = 0.032) were independently associated to advanced fibrosis.
Conclusion. A high frequency of undiagnosed advanced fibrosis and cirrhosis was observed in non-selected T2DM patients.
Screening of these conditions may be warranted in this patient population.
||NAFLD, NASH, Fibrosis, Diabetes, Insulin resistance, Obesity, Metabolic Syndrome, Mortality.
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>Annals of Hepatology
>Year 2016, Issue 5