2016, Number 3
Alerg Asma Inmunol Pediatr 2016; 25 (3)
Immunodeficiencies of the complement. Literature review Part I. Generalities and deficiencies of the classical pathway
Fuentes PJM, Jiménez PEN, Espinosa PSE
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Complement immunodeficiencies are defined as inherited immune system disorders that lead to the absence of the level or function of the protein. We can find deficiencies in complement activation pathways: classical alternative, lectins, or regulatory proteins. Deficiencies of the classical pathway are: C1q deficiency, C1r/s, C4, C2 and C3, which are associated with lupus erythematosus and infections by pyogenic microorganisms. Treatment are measures are support and is reported a case of a Pakistani teenager who at the age of 16 years hematopoietic cell transplantation related live donor (brother) was performed with good results. In this review we demonstrations by inherited disorders of the complement system classical pathway, leading to the total absence of level or function of proteins.
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Disponible en: http://registrolasid.org/
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