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2016, Number 4

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Mediciego 2016; 22 (4)

Clinical evaluation of VIMANG® in the treatment of oral homogenous leucoplakia

Mesa GRA, Díaz HMJ, Aragón AJE, Machado RS, Castañeda MR, Díaz MDM

Language: Spanish
References: 15
Page: 22-27
PDF size: 92.29 Kb.


ABSTRACT

Introduction: oral leukoplakia is the most frequent premalignant lesion in the world; in the province of Ciego de Ávila, more than 100 cases are diagnosed annually. Among the natural antioxidant products that can stop the evolutionary process of cancer is the VIMANG®, made from the bark of Mangifera indica L, with proven antioxidant effects in vivo and in vitro although its therapeutic use is poorly treated in the medical literature.
Objective: to evaluate the use of VIMANG® in the treatment of homogeneous oral leukoplakia.
Method: a monocentric study of therapeutic extension was carried out at the Maxillofacial Surgery Service of the Provincial General Teaching Hospital "Dr. Antonio Luaces Iraola" in Ciego de Ávila from January to December 2014; the sample consisted of 60 patients diagnosed with homogeneous oral leukoplakia, which were distributed in an experimental group (treated with VIMANG®) and a control group (treated with vitamins). The responses to treatment were evaluated in the initial, intermediate and final phases, as well as adverse reactions and patient compliance.
Results: the majority of patients in both groups had risk factors for the disease (smoking, alcoholism, clear skin and residents in urban areas); lesions on the lips were the most frequent. Regardless of these factors, 76,7 % of the patients in the experimental group and 63,3 % of the control group evolved favorably.
Conclusions: VIMANG® was more effective in treating homogeneous oral leukoplakia than conventional therapy.


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