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2016, Number 6

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Rev Mex Pediatr 2016; 83 (6)

Seroprevalence against Toxoplasma gondii in pediatric patients with HIV

Castillo-Tapia AN, Díaz-Peña R

Language: Spanish
References: 25
Page: 191-197
PDF size: 278.68 Kb.


ABSTRACT

Introduction: Toxoplasmosis predominates in immunocompromised patients as in HIV-AIDS, and there is high risk of reactivation in severe immunodeficiency. The worldwide prevalence is between 4-87%. The objective was to determine the prevalence of this infection in pediatric patients with HIV. Material and methods: Observational, cross-sectional, descriptive study. Which took place in a tertiary hospital care. We included HIV positive children 2-16 years old. IgG IgM was sought by ELISA kit for T. Gondii, and quantification of CD4 lymphocytes was measured by flow cytometry. Socio-demographic and risk factors for toxoplasmosis survey was conducted. All the analyses were descriptive. Authorized by the Committee on Research and ethics. Results: 26 children between 3-16 years, median 11. Women were eleven (42%) and 15 men (58%). Toxoplasma IgG was positive in five patients (19%), and IgM negative was negative for all patients. The positive IgG immune category was: 50% in severe immunosuppression, 14% moderate and 13% without immunosuppression. The median and percentage of CD4 positive serology was 1,021 and 24% CD4 cells. Conclusion: The prevalence of T. Gondii infection was lower than reported in adults from other countries and lower than the national average. No recent infection cases were identified.


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