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2016, Number 6

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Rev Mex Pediatr 2016; 83 (6)

Idiopathic neonatal hepatitis

Ledesma-Ramírez S

Language: Spanish
References: 35
Page: 208-214
PDF size: 279.09 Kb.


ABSTRACT

Idiopathic neonatal hepatitis (INH) is a term used to describe prolonged neonatal intrahepatic cholestasis in the first six months of life, whose histopathological lesion is characterized by the presence of “giant cells”, in the absence of other causes of type Infectious, genetic or obstructive. The frequency of INH is about 15% of cases of neonatal cholestasis. Idiopathic neonatal hepatitis is a diagnosis of exclusion in children with prolonged cholestasis. The decrease in its prevalence is due to advances in the biochemical and genetic diagnosis of hereditary and metabolic diseases that occur during early childhood. The role of biopsy in the diagnosis of neonatal hepatitis needs to be redefined to take advantage of the progress that has been made in genetic and immunohistochemical studies in the search for other causes of this entity. Medical management is supportive to optimize growth and development, as well as treating complications in case of a chronic liver disease.


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