2016, Number 3
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ABSTRACTIntroduction: Ulcerative colitis is an inflammatory bowel disease. Little is known about its causes, but genetic, environmental, immunological and bacterial factors have been suggested.
Objective: Describe the humoral immune response of patients with ulcerative colitis cared for at the Institute of Gastroenterology from January 2014 to April 2015.
Methods: A descriptive cross-sectional prospective study was conducted at the Institute of Gastroenterology from January 2014 to April 2015 which included all the patients diagnosed with ulcerative colitis. An evaluation was performed of clinical, endoscopic and histological variables as well as the results of immunological studies.
Results: A predominance was found of the female gender, the over-49 age group and white skin. There was also a predominance of alterations in complement components C3 and C4 and immunoglobulin G. Dependence and isolated correlation was observed between the results of immunological variables and the post-diagnosis time of evolution, the Truelove and Witts clinical scale, the degree of colonoscopic and histological activity, and the degree of dysplasia for p ‹ 0.05.
Conclusions: Immune response is a predictive factor for good evolution of the disease, but it does not allow to draw an inference about colonoscopic and histological activity. Immune response, on the other hand, is not related to the clinical evaluation scale of Truelove and Witts, the degree of dysplasia, clinical extraintestinal manifestations or post-diagnosis time of evolution.
López-Serrano P, Pérez-Calle JL, Pérez-Fernández MT, Fernández-Font JM, Boixeda de Miguel D, Fernández-Rodríguez CM, et al. Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: a Spanish case-control study. Scand J Gastroenterol [Internet]. 2010 [citado 12 de Mayo de 2014];45(12):1464-71. Disponible en: http://www.nature.com/ajg/journal/v101/n5/abs/ajg2006189a.html
Vind I, Riis L, Jespersgaard C, Jess T, Knudsen E, Pedersen N, et al. Genetic and environmental factors as predictors of disease severity and extent at time of diagnosis in an inception cohort of inflammatory bowel disease, Copenhagen County and City 2003-2005. J Crohns Colitis. junio 2008;2(2):162-9.
Noor SO, Ridgway K, Scovell L, Kemsley EK, Lund EK, Jamieson C, et al. Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol [Internet]. 2010 [citado 12 de Mayo de 2014];10(1):134. Disponible en: http://www.biomedcentral.com/1471-230X/10/134
Pastorelli L, De Salvo C, Mercado JR, Vecchi M, Pizarro TT. Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol [Internet]. 2013 [citado 12 de Mayo de 2015];4. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775315/
Kasran A, Boon L, Wortel CH, Hogezand RA, Schreiber S, Goldin E, et al. Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease. Aliment Pharmacol Ther [Internet]. 2005 [citado 12 de Mayo de 2014];22(2):111-22. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2005.02526.x/full
Qu N, Xu M, Mizoguchi I, Furusawa J, Kaneko K, Watanabe K, et al. Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. Clin Dev Immunol [Internet]. 2013 [citado 12 de Mayo de 2014];2013. Disponible en: http://downloads.hindawi.com/journals/cdi/2013/968549.pdf
Sepúlveda SE, Beltrán CJ, Peralta A, Rivas P, Rojas N, Figueroa C, et al. Enfermedad inflamatoria intestinal: Una mirada inmunológica. Rev Médica Chile [Internet]. 2008 [citado 12 de Mayo de 2014];136(3):367-75. Disponible en: http://www.scielo.cl/scielo.php?pid=S003498872008000300014&script=sci_arttext
Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, et al. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol [Internet]. 2007 [citado 12 de Mayo de 2014];5(12):1424-9. Disponible en: http://www.sciencedirect.com/science/article/pii/S154235650700715X
Khounlotham M, Kim W, Peatman E, Nava P, Medina-Contreras O, Addis C, et al. Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis. Immunity [Internet]. 2012 [citado 12 de Mayo de 2014];37(3):563-73. Disponible en: http://www.sciencedirect.com/science/article/pii/S1074761312003809