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2017, Number 2

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Rev Fac Med UNAM 2017; 60 (2)

Maturative lineages of cells that regenerate the liver

Villegas-Serrano EY, Aguilar-Vega L, Pérez-Armendáriz EM, Zurabian R

Language: Spanish
References: 26
Page: 5-10
PDF size: 392.84 Kb.


ABSTRACT

Different cellular lineages participate in liver regeneration. Quiescent hepatocytes may respond to a mild liver injury with moderate cell division. Meanwhile, stem and progenitor cells are responsible for the large restitution of a severe damaged organ. Eight maturational lineages are in the liver, each one with a different maturity grade. Four subpopulations out of eight express stem or progenitor cell markers are found within intrahepatic niches such as the canals of Hering and the portal vein. Each structure is able to continue its differentiation if a stimuli is received. Recently, a new extra-hepatic stem niche with a heterogeneous cellular composition was found between the large biliary ducts and the pancreas. Stem or progenitor cells contained in these compartments express early stem markers and are considered as a precursor of hepatic stem cells.


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