2017, Number 1
Amphetamine-related dilatated cardiomyopathy: a growing phenomenon. Case report
Language: English
References: 16
Page: 35-39
PDF size: 276.82 Kb.
ABSTRACT
The consumption of amphetamines and its derivatives, either recreationally or for working reasons, is widespread, currently being the second most consumed drug worldwide. An often overlooked aspect of this drug has been its toxicity over the myocardium. In the following text we describe the case of a young male patient, without any relevant previous conditions, except alcohol ingestion in moderate quantity along with 3 years of using amphetamine-type stimulants and cocaine, whose main clinical manifestation was sudden onset dyspnea with minimal effort, which progressed to resting dyspnea after the ingestion of several tablets of clobenzorex, which was initially hospitalized with a diagnostic of pneumonia and finally diagnosed with a dilatated cardiomyopathy. Substance abuse should be a warning flag on patients presenting with dyspnea in order to think of a possible drug related cardiomyopathy, avoiding that way undue delays on appropriate diagnosis and treatment.REFERENCES
Villatoro-Velázquez JA, Medina-Mora ME, Fleiz-Bautista C, Téllez-Rojo MM, Mendoza-Alvarado LR, Romero-Martínez M et al. Encuesta Nacional de Adicciones 2011: Reporte de drogas [National Addiction Poll 2011: Drug Report]. México D.F. (MX): INPRFM; 2012. p. 71. Available from: http://www.conadic.salud.gob.mx/pdfs/ENA_2011_DROGAS_ILICITAS_.pdf
Comisión Nacional Contra las Adicciones (MX). Informe ejecutivo: I. Generalidades de los estimulantes tipo anfetamínico (énfasis en metanfetamina) [Executive summary: I. Generalities of amphetamine type stimulants (emphasis on metamphetamine)]. Mexico D.F. (MX): Secretaría de Salud; 2013. p. 5. Report No.: 1. Available from: http://www.conadic.salud.gob.mx/pdfs/informe_anfetaminas.pdf
Brouwer KC, Case P, Ramos R, Magis-Rodríguez R, Bucardo J, Patterson TL et al. Trends in production, trafficking, and consumption of methamphetamine and cocaine in Mexico. Subst Use Misuse [Internet]. 2006 [cited 2016 Jul 11]; 41 (5): 707-727. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757051/pdf/nihms124574.pdf
Kaye S, McKetin R, Duflou J, Darke J. Methamphetamine and cardiovascular pathology: a review of the evidence. Addiction [Internet]. 2007 [cited 2016 Nov 20]; 102 (8): 1204-1211. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2007.01874.x/abstract;jsessionid=FFCC98BE79D6B57DA4E0D45121292A35.f02t02
Huang CY, Chen WL, Chen JH, Chang SH, Chan CM. Methamphetamine-induced cardiotoxicity with heart failure in a young adult: a case report and literature review. J Emerg Crit Care Med [Internet]. 2013 [cited 2016 Jun 09]; 24 (2): 61-64. Available from: http://www.seccm.org.tw/magazine/pdf/201324_0203.pdf
Richardson PJ, Wodak AD, Atkinson L, Saunders JB, Jewitt DE. Relation between alcohol intake, myocardial enzyme activity, and myocardial function in dilated cardiomyopathy. Evidence for the concept of alcohol induced heart muscle disease. Br Heart J [Internet]. 1986 [cited 2016 Jun 09]; 56 (2): 165-170. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236828/pdf/brheartj00104-0057.pdf
Mendelson J, Jones RT, Upton R, Peyton J 3rd. Methamphetamine and ethanol interactions in humans. Clin Pharmacol Ther [Internet]. 1995 [cited 2016 Jun 20]; 57 (5): 559-568. Available from: http://onlinelibrary.wiley.com/doi/10.1016/0009-9236(95)90041-1/abstract;jsessionid=4604113C2E5F564D25526561D6D4A15F.f02t04
Klimas J. Drug-induced cardiomyopathies. In: Veselka J, editor. Cardiomyopathies – From basic research to clinical management [Internet]. InTech; 2012 [cited 2016 Jun 20]. Chapter 16. Available from: http://www.intechopen.com/books/cardiomyopathies-from-basic-research-to-clinical-management/drug-induced-cardiomyopathies DOI: 10.5772/29349.